Interactions Between Antidepressants and Intestinal Microbiota

被引:0
|
作者
Feiyu Xu
Qinglian Xie
Weihong Kuang
Zaiquan Dong
机构
[1] Sichuan University,West China School of Medicine
[2] West China Hospital,Department of Outpatient
[3] Sichuan University,Department of Psychiatry and National Clinical Research Center for Geriatrics
[4] Mental Health Center of West China Hospital,undefined
[5] Sichuan University,undefined
[6] West China Hospital,undefined
[7] Sichuan University,undefined
来源
Neurotherapeutics | 2023年 / 20卷
关键词
Depression; Antidepressants; Intestinal microbiota; Interaction; Metabolism;
D O I
暂无
中图分类号
学科分类号
摘要
The microbiota-gut-brain axis has been shown to influence human health and diseases, including depression. The interactions between drugs and intestinal microbiota are complex and highly relevant to treat diseases. Studies have shown an interaction between antidepressants and intestinal microbiota. Antidepressants may alter the abundance and composition of intestinal microbiota, which are closely related to the treatment outcomes of depression. Intestinal microbiota can influence the metabolism of antidepressants to change their availability (e.g., tryptophan can be metabolized to kynurenine by intestinal microbiota) and regulate their absorption by affecting intestinal permeability. In addition, the permeability of the blood–brain barrier can be altered by intestinal microbiota, influencing antidepressants to reach the central nervous system. Bioaccumulation is also a type of drug–microbiota interaction, which means bacteria accumulate drugs without biotransformation. These findings imply that it is important to consider intestinal microbiota when evaluating antidepressant therapy regimens and that intestinal microbiota can be a potential target for depression treatment.
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页码:359 / 371
页数:12
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