Interactions between the intestinal microbiota and innate lymphoid cells

被引：17
|
作者：
Chen, Vincent L. [1 ]
Kasper, Dennis L. [1 ]
机构：
[1] Harvard Med Sch, Dept Microbiol & Immunol, Boston, MA 02115 USA
来源：
GUT MICROBES | 2014年 / 5卷 / 01期
关键词：
microbiota; intestinal immunity; Bacteriodes fragilis; polysaccharide A; innate lymphoid cell; lymphoid tissue inducer cell;
D O I：
10.4161/gmic.27289
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The mammalian intestine must manage to contain 100 trillion intestinal bacteria without inducing inappropriate immune responses to these microorganisms. The effects of the immune system on intestinal microorganisms are numerous and well-characterized, and recent research has determined that the microbiota influences the intestinal immune system as well. In this review, we first discuss the intestinal immune system and its role in containing and maintaining tolerance to commensal organisms. We next introduce a category of immune cells, the innate lymphoid cells, and describe their classification and function in intestinal immunology. Finally, we discuss the effects of the intestinal microbiota on innate lymphoid cells.
引用
收藏
页码：129 / 140
页数：12
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