Association study of miR-146a, miR-149, miR-196a2, and miR-499 polymorphisms with venous thromboembolism in a Korean population

被引：0
|
作者：
Jung Oh Kim
Hyun Woo Kim
Hui Jeong An
Ok Joon Kim
Jisu Oh
So Young Chong
Won-Il Choi
Doyeun Oh
Nam Keun Kim
机构：
[1] CHA University,Department of Biomedical Science, College of Life Science
[2] CHA University,Department of Neurology, CHA Bundang Medical Center, School of Medicine
[3] CHA University,Department of Internal Medicine, CHA Bundang Medical Center
[4] Keimyung University Dongsan Medical Center,Department of Internal Medicine, Keimyung University School of Medicine
来源：
Journal of Thrombosis and Thrombolysis | 2019年 / 47卷
关键词：
Deep vein thrombosis; MicroRNA; Single nucleotide polymorphism; Pulmonary embolism;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Despite much progress in microRNA (miRNA) research, information regarding the association between miRNAs and venous thromboembolism (VTE), especially in Asian patients, remains limited. This case-control study sought to determine the correlation between the presence of polymorphisms in the genes encoding the miRNAs miR-146a, miR-149, miR-196a2, miR-499, and VTE in Korean patients. We observed no statistically significant differences in the genotype frequency of miRNA polymorphisms between 300 control individuals and 203 VTE patients. However, we observed a significant association between three allelic combinations of miRNA polymorphisms and VTE risk. Overall, our findings suggest that specific miRNA polymorphisms are associated with the risk of VTE in a Korean population.
引用
收藏
页码：255 / 262
页数：7
相关论文
共 50 条
  • [11] miRNA polymorphisms (miR-146a, miR-149, miR-196a2 and miR-499) are associated with the risk of coronary artery disease
    Sung, Jung-Hoon
    Kim, Sang-Hoon
    Yang, Woo-In
    Kim, Won-Jang
    Moon, Jae-Youn
    Kim, In Jai
    Cha, Dong-Hun
    Cho, Seung-Yun
    Kim, Jung Oh
    Kim, Kyeong Ah
    Kim, Ok-Joon
    Lim, Sang-Wook
    Kim, Nam-Keun
    [J]. MOLECULAR MEDICINE REPORTS, 2016, 14 (03) : 2328 - 2342
  • [12] Association of microRNA Polymoprhisms (miR-146a, miR-149, miR-196a2 and miR-499) with risk of Coronary Artery Disease
    Agiannitopoulos, K.
    Papadopoulou, M.
    Sozou, A.
    Kolovou, V.
    Babalis, D.
    Mertzanos, G.
    Tsamis, K.
    Lamnissou, K. M.
    [J]. EUROPEAN JOURNAL OF HUMAN GENETICS, 2019, 27 : 1917 - 1917
  • [13] Associations of MicroRNA Polymorphisms (miR-146a, miR-196a2, and miR-499) with the Risk of Hypertension in the Korean Population
    Kim, Young Ree
    Hong, Seung-Ho
    [J]. GENETIC TESTING AND MOLECULAR BIOMARKERS, 2016, 20 (08) : 420 - 426
  • [14] Functional miR-146a, miR-149, miR-196a2 and miR-499 polymorphisms and the susceptibility to hepatocellular carcinoma: An updated meta-analysis
    Zheng, Lei
    Zhuang, Chunbo
    Zhao, Junwei
    Ming, Liang
    [J]. CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY, 2017, 41 (06) : 664 - 676
  • [15] Genetic variants in miR-146a, miR-149, miR-196a2, miR-499 and their influence on relative expression in lung cancers
    Vinci, Serena
    Gelmini, Stefania
    Pratesi, Nicola
    Conti, Simona
    Malentacchi, Francesca
    Simi, Lisa
    Pazzagli, Mario
    Orlando, Claudio
    [J]. CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2011, 49 (12) : 2073 - 2080
  • [16] Association of the miR-146a, miR-149, miR-196a2 and miR-499 polymorphisms with susceptibility to pulmonary tuberculosis in the Chinese Uygur, Kazak and Southern Han populations
    Zhang, Xing
    Li, Yanyuan
    Li, Xiang
    Zhang, Wanjiang
    Pan, Zhifen
    Wu, Fang
    Wang, Chong
    Chen, Zhongliang
    Jiang, Tingting
    Xu, Dandan
    Ping, Zepeng
    Liu, Jiyan
    Liu, Changming
    Li, Zhongjie
    Li, Ji-Cheng
    [J]. BMC INFECTIOUS DISEASES, 2015, 15 : 1 - 11
  • [17] Association of the miR-146a, miR-149, miR-196a2 and miR-499 polymorphisms with susceptibility to pulmonary tuberculosis in the Chinese Uygur, Kazak and Southern Han populations
    Xing Zhang
    Yanyuan Li
    Xiang Li
    Wanjiang Zhang
    Zhifen Pan
    Fang Wu
    Chong Wang
    Zhongliang Chen
    Tingting Jiang
    Dandan Xu
    Zepeng Ping
    Jiyan Liu
    Changming Liu
    Zhongjie Li
    Ji-Cheng Li
    [J]. BMC Infectious Diseases, 15
  • [18] Association between single nucleotide polymorphism in miR-499, miR-196a2, miR-146a and miR-149 and prostate cancer risk in a sample of Iranian population
    Hashemi, Mohammad
    Moradi, Nazanin
    Ziaee, Seyed Amir Mohsen
    Narouie, Behzad
    Soltani, Mohammad Hosein
    Rezaei, Maryam
    Shahkar, Ghazaleh
    Taheri, Mohsen
    [J]. JOURNAL OF ADVANCED RESEARCH, 2016, 7 (03) : 491 - 498
  • [19] Associations of Single Nucleotide Polymorphisms in miR-146a, miR-196a, miR-149 and miR-499 with Colorectal Cancer Susceptibility
    Du, Wei
    Ma, Xue-Lei
    Zhao, Chong
    Liu, Tao
    Du, Yu-Liang
    Kong, Wei-Qi
    Wei, Ben-Ling
    Yu, Jia-Yun
    Li, Yan-Yan
    Huang, Jing-Wen
    Li, Zi-Kang
    Liu, Lei
    [J]. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2014, 15 (02) : 1047 - 1055
  • [20] miR-146a, miR-196a2, miR-499, and miR-149 linked with susceptibility to acute lymphoblastic leukemia: A case-control study in Tunisia
    Dhiflaoui, Amani
    Mahjoub, Sana
    Chayeb, Vera
    Achour, Bechir
    Chouchen, Saoussen
    Ben Abdennebi, Hassen
    Mahjoub, Touhami
    Almawi, Wassim Y.
    [J]. GENE, 2022, 834
12345