Octaarginine-modified multifunctional envelope-type nanoparticles for gene delivery

被引：0

作者：

I A Khalil

K Kogure

S Futaki

S Hama

H Akita

M Ueno

H Kishida

M Kudoh

Y Mishina

K Kataoka

M Yamada

H Harashima

机构：

[1] Graduate School of Pharmaceutical Sciences,

[2] Hokkaido University,undefined

[3] Kita-ku,undefined

[4] Sapporo,undefined

[5] Hokkaido,undefined

[6] Japan,undefined

[7] The Core Research for Evolutional Science and Technology (CREST),undefined

[8] Precursory Research for Embryonic Science and Technology,undefined

[9] Japan Science and Technology Agency (JST),undefined

[10] Shibuya,undefined

[11] Institute for Chemical Research,undefined

[12] Kyoto University,undefined

[13] Faculty of Pharmaceutical Sciences,undefined

[14] Toyama Medical and Pharmaceutical University,undefined

[15] Sugitani,undefined

[16] Yamada Research Unit,undefined

[17] RIKEN Brain Science Institute,undefined

[18] National Institute of Environmental Health,undefined

[19] Research Triangle Park,undefined

[20] Graduate School of Engineering,undefined

[21] The University of Tokyo,undefined

[22] Hongo,undefined

来源：

Gene Therapy | 2007年 / 14卷

关键词：

non-viral gene delivery system; programmed packaging; octaarginine; multifunctional envelope-type nano device; topical application; hair growth;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

This study describes a multifunctional envelope-type nano device (MEND) that mimics an envelope-type virus based on a novel packaging strategy. MEND particles contain a DNA core packaged into a lipid envelope modified with an octaarginine peptide. The peptide mediates internalization via macropinocytosis, which avoids lysosomal degradation. MEND-mediated transfection of a luciferase expression plasmid achieved comparable efficiency to adenovirus-mediated transfection, with lower associated cytotoxicity. Furthermore, topical application of MEND particles containing constitutively active bone morphogenetic protein (BMP) type IA receptor (caBmpr1a) gene had a significant impact on hair growth in vivo. These data demonstrate that MEND is a promising non-viral gene delivery system that may provide superior results to existing non-viral gene delivery technologies.

引用

页码：682 / 689

页数：7

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