Synthesis of 3-aryl-2-[hydroxy(diaryl)methyl]-4-oxo-3,4-dihydroquinazolines

被引：0
|
作者：
L. A. Shemchuk
V. P. Chernykh
D. V. Levashov
K. M. Sytnik
L. M. Shemchuk
机构：
[1] National Pharmaceutical University,
来源：
Russian Journal of Organic Chemistry | 2010年 / 46卷
关键词：
Anthranilic Acid; Isatoic Anhydride; Diethyl Oxalate; Diphenyl Oxide; Anthranilamides;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
By heating arylamides of N-ethoxalylanthranilic acid in the acetic acid mediun in the presence of triethylamine the corresponding ethyl 3-aryl-4-oxo-3,4-dihydroquinazoline-2-carboxylates were obtained. The latter in the conditions of the Grignard reaction formed 3-aryl-2-[hydroxy-(diaryl)methyl]-4-oxo-3,4-dihydroquinazolines.
引用
收藏
页码：1687 / 1690
页数：3
相关论文
共 50 条
  • [21] 2-Methyl-3-(2-methylphenyl)-4-oxo-3,4-dihydroquinazolin-8-yl benzoate
    El-Azab, Adel S.
    Abdel-Aziz, Alaa A. -M.
    Ng, Seik Weng
    Tiekink, Edward R. T.
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2012, 68 : O732 - U2247
  • [22] 4-oxo-3,4-dihydroquinazolin-3-yl-methyl N,N-diisopropylcarbamodithioate
    Liu, Ming-Zhen
    Huang, Wei
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2007, 63 : O4299 - U3196
  • [23] Syntheses of 3,4-and 1,4-dihydroquinazolines from 2-aminobenzylamine
    Diaz, Jimena E.
    Ranieri, Silvia
    Gruber, Nadia
    Orelli, Liliana R.
    BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2017, 13 : 1470 - 1477
  • [24] Methyl 2-((3-(3-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)thio)acetate
    Molnar, Maja
    Komar, Mario
    Jerkovic, Igor
    MOLBANK, 2022, 2022 (03)
  • [25] A convenient method for the synthesis of 3,4-dihydroquinazolines from iminoester hydrochlorides via microwave irradiation
    Karaali, Nesrin
    JOURNAL OF CHEMICAL RESEARCH, 2019, 43 (3-4) : 140 - 143
  • [26] A SINGLE-STEP PROCEDURE FOR SYNTHESIS OF 2,4- AND 2,3,4-SUBSTITUTED 3,4-DIHYDROQUINAZOLINES
    SURI, KA
    SATTI, NK
    MAHAJAN, B
    SURI, OP
    DHAR, KL
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1993, 32 (11): : 1171 - 1172
  • [27] Synthesis of substituted 4-oxo-2-thioxo-1,2,3,4-tetrahydroquinazolines and 4-oxo-3,4-dihydroquinazoline-2-thioles
    Ivachtchenko, AV
    Kovalenko, SM
    Drushlyak, OG
    JOURNAL OF COMBINATORIAL CHEMISTRY, 2003, 5 (06): : 775 - 788
  • [28] 2-Methyl-3-(2-methylphenyl)-4-oxo-3,4dihydroquinazolin-8-yl 4-chlorobenzoate
    El-Azab, Adel S.
    Abdel-Aziz, Alaa A. -M.
    Alanazi, Amer M.
    Ng, Seik Weng
    Tiekink, Edward R. T.
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2012, 68 : O2052 - +
  • [29] 2-Methyl-3-(2-methylphenyl)-4-oxo-3,4dihydroquinazolin-8-yl 4-methylbenzoate
    El-Azab, Adel S.
    Abdel-Aziz, Alaa A. -M.
    Ng, Seik Weng
    Tiekink, Edward R. T.
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2012, 68 : O734 - U2256
  • [30] Studies on quinazoline chemistry 6*. Synthesis and alkylation of 2-substituted 4,4-diphenyl-3,4-dihydroquinazolines
    Elena V. Gromachevskaya
    Elena A. Kaigorodova
    Leonid D. Konyushkin
    Chemistry of Heterocyclic Compounds, 2017, 53 : 545 - 552
12345