Rapid expansion and international spread of M1UK in the post-pandemic UK upsurge of Streptococcus pyogenes

被引：27

作者：

Vieira, Ana ^{[1
,2
,3
]}

Wan, Yu ^{[1
,3
,4
,5
]}

Ryan, Yan ^{[6
]}

Li, Ho Kwong ^{[1
,2
]}

Guy, Rebecca L. ^{[4
,5
]}

Papangeli, Maria ^{[1
,2
]}

Huse, Kristin K. ^{[1
,2
]}

Reeves, Lucy C. ^{[1
,2
]}

Soo, Valerie W. C. ^{[1
,2
]}

Daniel, Roger ^{[6
]}

Harley, Alessandra ^{[6
]}

Broughton, Karen ^{[6
]}

Dhami, Chenchal ^{[6
]}

Ganner, Mark ^{[6
]}

Ganner, Marjorie A. ^{[6
]}

Mumin, Zaynab ^{[6
]}

Razaei, Maryam ^{[6
]}

Rundberg, Emma ^{[6
]}

Mammadov, Rufat ^{[6
]}

Mills, Ewurabena A. ^{[1
,2
]}

Sgro, Vincenzo ^{[1
]}

Mok, Kai Yi ^{[1
]}

Didelot, Xavier ^{[7
,8
]}

Croucher, Nicholas J. ^{[9
,10
]}

Jauneikaite, Elita ^{[3
,9
,10
]}

Lamagni, Theresa ^{[3
,4
,5
]}

Brown, Colin S. ^{[3
,4
,5
]}

Coelho, Juliana ^{[3
,4
,5
,6
]}

Sriskandan, Shiranee ^{[1
,2
,3
]}

机构：

[1] Imperial Coll London, Dept Infect Dis, London, England

[2] Imperial Coll London, Ctr Bacterial Resistance Biol, London, England

[3] Imperial Coll London, NIHR Hlth Protect Res Unit Healthcare Associated I, London, England

[4] UK Hlth Secur Agcy, Healthcare Associated Infect Fungal, AMR, AMU, London, England

[5] UK Hlth Secur Agcy, Sepsis Div, London, England

[6] UK Hlth Secur Agcy, Reference Serv Div, London, England

[7] Univ Warwick, Sch Life Sci, Coventry, England

[8] Univ Warwick, Dept Stat, Coventry, England

[9] Imperial Coll London, Sch Publ Hlth, London, England

[10] Imperial Coll London, MRC Ctr Global Infect Dis Anal, London, England

来源：

NATURE COMMUNICATIONS | 2024年 / 15卷 / 01期

基金：

英国医学研究理事会;

关键词：

SCARLET FEVER; INFECTIONS; ENGLAND;

D O I：

10.1038/s41467-024-47929-7

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The UK observed a marked increase in scarlet fever and invasive group A streptococcal infection in 2022 with severe outcomes in children and similar trends worldwide. Here we report lineage M1(UK) to be the dominant source of invasive infections in this upsurge. Compared with ancestral M1(global) strains, invasive M1(UK) strains exhibit reduced genomic diversity and fewer mutations in two-component regulator genes covRS. The emergence of M1(UK) is dated to 2008. Following a bottleneck coinciding with the COVID-19 pandemic, three emergent M1(UK) clades underwent rapid nationwide expansion, despite lack of detection in previous years. All M1(UK) isolates thus-far sequenced globally have a phylogenetic origin in the UK, with dispersal of the new clades in Europe. While waning immunity may promote streptococcal epidemics, the genetic features of M1(UK) point to a fitness advantage in pathogenicity, and a striking ability to persist through population bottlenecks.

引用

页数：11

共 22 条

[21] Characterization of a novel covS SNP identified in Australian group A Streptococcus isolates derived from the M1UK lineage
Richter, Johanna
Cork, Amanda J.
Ong, Yvette
Keller, Nadia
Hayes, Andrew J.
Schembri, Mark A.
Jennison, Amy V.
Davies, Mark R.
Schroder, Kate
Walker, Mark J.
Brouwer, Stephan
MBIO, 2025, 16 (02)
[22] Increase in bloodstream infections caused by emm1 group A Streptococcus correlates with emergence of toxigenic M1UK, Belgium, May 2022 to August 2023
Rodriguez-Ruiz, Juan Pablo
Lin, Qiang
Lammen, Christine
Smeesters, Pierre R.
van Kleef-van Koeveringe, Stefanie
Matheeussen, Veerle
Malhotra-Kumar, Surbhi
EUROSURVEILLANCE, 2023, 28 (36)

← 1 2 3 →