Detection of Agonistic Activities Against Five Human Nuclear Receptors in River Environments of Japan Using a Yeast Two-Hybrid Assay

被引：0
|
作者：
Daisuke Inoue
Koki Nakama
Hisae Matsui
Kazunari Sei
Michihiko Ike
机构：
[1] Osaka University,Division of Sustainable Energy and Environmental Engineering
来源：
Bulletin of Environmental Contamination and Toxicology | 2009年 / 82卷
关键词：
Agonistic activity; Nuclear receptor; Retinoic acid receptor; River water environment;
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暂无
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学科分类号：
摘要：
A total of 16 water samples from four rivers in Japan were examined for their agonistic activities against five human nuclear receptors (estrogen receptor [ER] α, thyroid hormone receptor α, retinoic acid receptor [RAR] α, retinoid X receptor α, and vitamin D receptor) by using a yeast two-hybrid assay. The results suggest that the river environment is contaminated with endocrine disrupting chemicals (EDCs) that can interact with a variety of nuclear receptors and that contamination with those that have RAR agonistic activity may be more serious than contamination with well-known EDCs that act as ER agonists.
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页码：399 / 404
页数：5
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