Serum sodium and risk of hypertension: a cohort study

被引:0
|
作者
Huan Hu
Masafumi Eguchi
Takako Miki
Takeshi Kochi
Isamu Kabe
Akiko Nanri
Graham A. Macgregor
Tetsuya Mizoue
Feng J. He
机构
[1] Queen Mary University of London,Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry
[2] National Center for Global Health and Medicine,Department of Epidemiology and Prevention
[3] National Institute of Occupational Safety and Health,Research Center for Prevention from Radiation Hazards of Workers
[4] Furukawa Electric Co.,Department of Food and Health Sciences, International College of Arts and Sciences
[5] Ltd.,undefined
[6] KUBOTA Corporation Co.,undefined
[7] Ltd.,undefined
[8] Fukuoka Women’s University,undefined
来源
Hypertension Research | 2022年 / 45卷
关键词
Blood pressure; Hypertension; Serum sodium;
D O I
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中图分类号
学科分类号
摘要
This study aimed to investigate the cross-sectional association between serum sodium and blood pressure at baseline and, more importantly, investigate the prospective association between serum sodium and the risk of incident hypertension. We used data from 1 638 workers aged 18 to 71 years who participated in 2015–2016 survey of the Furukawa Nutrition and Health Study. During a maximum follow-up of 3 years, 229 participants developed hypertension. Multivariable linear regression models were used to evaluate the cross-sectional association. The Cox proportional hazards model was used to calculate the hazard ratio and 95% confidence interval of incident hypertension across quartiles of serum sodium (137–140, 141–142, 143, and 144–147 mmol/L). In the cross-sectional analysis, we did not observe a significant association between serum sodium and blood pressure at baseline. In the prospective analysis, the multivariable-adjusted hazard ratios (95% confidence intervals) for incident hypertension were 1.03 (0.71–1.51), 1.35 (0.87–2.08), and 1.46 (0.97–2.20) for the upper three quartiles of the serum sodium levels compared with the lowest quartile (P for trend=0.02). When serum sodium was treated as a continuous variable, the multivariable-adjusted hazard ratio for hypertension was 1.10 (1.03–1.18). The association was slightly attenuated after additionally adjusting for baseline blood pressure, with a hazard ratio of 1.08 (1.00–1.16) for a 1 mmol/L increase in serum sodium. In conclusion, an elevated serum sodium level was associated with an increased risk of developing hypertension, suggesting that serum sodium could be a potential risk factor for hypertension.
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页码:354 / 359
页数:5
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