NAD+ boosting brings tears to aging eyes

被引：0

作者：

Mitsukuni Yoshida

Rajendra S. Apte

机构：

[1] Washington University School of Medicine,Academic Scholar Advancement Program, Department of Anesthesiology

[2] Washington University School of Medicine,Department of Ophthalmology and Visual Sciences

[3] Washington University School of Medicine,Department of Medicine

[4] Washington University School of Medicine,Department of Developmental Biology

来源：

Nature Aging | 2022年 / 2卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

As the elderly population continues to grow exponentially, dry eye disease is becoming increasingly common. In this issue, Sasaki and colleagues identified a NAD+-regulated steroidogenic pathway in the eye that supports the normal function of meibomian glands, and show that increasing the availability of NAD+ can alleviate the dry eye phenotype of aged mice.

引用

页码：97 / 99

页数：2

共 50 条

[41] NAD+ controls neural stem cell fate in the aging brain
Wiley, Christopher
Campisi, Judith
EMBO JOURNAL, 2014, 33 (12): : 1289 - 1291
[42] Pathobiochemistry of Aging and Neurodegeneration: Deregulation of NAD+ Metabolism in Brain Cells
Kolotyeva, Nataliya A.
Groshkov, Alexander A.
Rozanova, Nataliya A.
Berdnikov, Arseniy K.
Novikova, Svetlana V.
Komleva, Yulia K.
Salmina, Alla B.
Illarioshkin, Sergey N.
Piradov, Mikhail A.
BIOMOLECULES, 2024, 14 (12)
[43] Preclinical Characterization of Pharmacologic NAD+ Boosting as a Promising Therapeutic Approach in Rheumatoid Arthritis
Perez-Sanchez, Carlos
Escudero-Contreras, Alejandro
Cerdo, Tomas
Sanchez-Mendoza, Luz Marina
Llamas-Urbano, Adrian
de la Rosa, Ivan Arias
Perez-Rodriguez, Miguel
Munoz-Barrera, Laura
del Carmen Abalos-Aguilera, Maria
Barbarroja, Nuria
Calvo, Jerusalem
Ortega-Castro, Rafaela
Ruiz-Vilchez, Desiree
Moreno, Juan Antonio
Buron, Maria Isabel
Antonio Gonzalez-Reyes, Jose
Collantes-Estevez, Eduardo
Lopez-Pedrera, Chary
Villalba, Jose Manuel
ARTHRITIS & RHEUMATOLOGY, 2023, 75 (10) : 1749 - 1761
[44] The NAD+/PARP1/SIRT1 Axis in Aging
Mendelsohn, Andrew R.
Larrick, James W.
REJUVENATION RESEARCH, 2017, 20 (03) : 244 - 247
[45] Nicotinamide Adenine Dinucleotide (NAD+) Biosynthesis in the Regulation of Metabolism, Aging, and Neurodegeneration
Ross, Stephanie Maxine
HOLISTIC NURSING PRACTICE, 2021, 35 (04) : 230 - 232
[46] Circadian cardiac NAD+ metabolism, from transcriptional regulation to healthy aging
Carpenter, Bryce J.
Dierickx, Pieterjan
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2022, 323 (04): : C1168 - C1176
[47] NAD+ centric mechanisms and molecular determinants of skeletal muscle disease and aging
Sabrina Wagner
Ravikumar Manickam
Marco Brotto
Srinivas M. Tipparaju
Molecular and Cellular Biochemistry, 2022, 477 : 1829 - 1848
[48] Partial Reversal of Skeletal Muscle Aging by Restoration of Normal NAD+ Levels
Mendelsohn, Andrew R.
Larrick, James W.
REJUVENATION RESEARCH, 2014, 17 (01) : 62 - 69
[49] NAD+ Metabolism and Interventions in Premature Renal Aging and Chronic Kidney Disease
Chanvillard, Lucie
Tammaro, Alessandra
Sorrentino, Vincenzo
CELLS, 2023, 12 (01)
[50] NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome
Fang, Evandro F.
Hou, Yujun
Lautrup, Sofie
Jensen, Martin Borch
Yang, Beimeng
SenGupta, Tanima
Caponio, Domenica
Khezri, Rojyar
Demarest, Tyler G.
Aman, Yahyah
Figueroa, David
Morevati, Marya
Lee, Ho-Joon
Kato, Hisaya
Kassahun, Henok
Lee, Jong-Hyuk
Filippelli, Deborah
Okur, Mustafa Nazir
Mangerich, Aswin
Croteau, Deborah L.
Maezawa, Yoshiro
Lyssiotis, Costas A.
Tao, Jun
Yokote, Koutaro
Rusten, Tor Erik
Mattson, Mark P.
Jasper, Heinrich
Nilsen, Hilde
Bohr, Vilhelm A.
NATURE COMMUNICATIONS, 2019, 10 (1)

← 1 2 3 4 5 →