Effect of crystal form onin vivo topical anti-inflammatory activity of corticosteroids

被引：0
|
作者：
Young-Taek Sohn
Sun-Young Kim
机构：
[1] Duksung Womenís University,College of Pharmacy
来源：
Archives of Pharmacal Research | 2002年 / 25卷
关键词：
Corticosteroids; Crystal Form; Topical anti-inflammation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The aim of this study was to gain information on the effects of the crystal form of corticosteroids on the topical anti-inflammatory activity. Two different crystal forms, Form A and Form B, of the drugs of prednicarbate, hydrocortisone, betamethasone 17-valerate, prednisolone, and methyl prednisolone were prepared and their topical anti-inflammatory activities were measured using arachidonic acid induced ear edema assay in mice. Two crystal forms of the drugs showed differences in anti-inflammatory activity. Among the drugs examined, Form B of prednicarbate and betamethasone 17-valerate showed significantly more potent anti-inflammatory activities as compared to their Form A.
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页码：556 / 559
页数：3
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