Fibulin 1 is downregulated through promoter hypermethylation in gastric cancer

被引：0

作者：

Y Y Cheng

H Jin

X Liu

J M T Siu

Y P Wong

E K O Ng

J Yu

W-k Leung

J J Y Sung

F K L Chan

机构：

[1] Institute of Digestive Disease,Department of Medicine and Therapeutics

[2] Faculty of Medicine,undefined

[3] Li Ka Shing Institute of Health Sciences,undefined

[4] The Chinese University of Hong Kong,undefined

来源：

British Journal of Cancer | 2008年 / 99卷

关键词：

methylation; tumour suppressor gene; gastric cancer;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Tumour suppressor genes (TSGs) were frequently inactivated through promoter hypermethylation in gastric carcinoma as well as pre-malignant gastric lesions, suggesting that promoter hypermethylation can be used as a marker to define novel TSGs and also biomarkers for early detection of gastric cancer. In an effort to search for such genes aberrantly methylated in gastric cancer development, fibulin 1 (FBLN1) was found as a candidate TSG epigenetically downregulated in gastric cancer. FBLN1 expression was downregulated in all of gastric cancer cell lines used (100%, 7 out of 7) and the primary gastric carcinoma tissues (84%, 86 out of 102) and significantly restored after pharmacological demethylation. Hypermethylation of the FBLN1 promoter was frequently (71%, 5 out of 7) detected in gastric cancer cell lines and primary gastric carcinoma tissues. Ectopic expression of FBLN1 led to the growth inhibition of gastric cancer cells through the induction of apoptosis. In summary, FBLN1 was identified as a novel candidate TSG epigenetically downregulated in gastric cancer.

引用

页码：2083 / 2087

页数：4

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