Inhibition of Microglial NLRP3 with MCC950 Attenuates Microglial Morphology and NLRP3/Caspase-1/IL-1β Signaling In Stress-induced Mice

被引:0
|
作者
Qing Liu
Man-Man Zhang
Min-Xia Guo
Qiu-Ping Zhang
Na-Zhi Li
Jie Cheng
Shi-Le Wang
Guang-Hui Xu
Cheng-Fu Li
Ji-Xiao Zhu
Li-Tao Yi
机构
[1] Huaqiao University,Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering
[2] Jiangxi University of Chinese Medicine,Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine
[3] Xiamen Hospital of Traditional Chinese Medicine,Institute of Pharmaceutical Engineering
[4] Xiamen Medicine Research Institute,Fujian Provincial Key Laboratory of Biochemical Technology
[5] Huaqiao University,undefined
[6] Huaqiao University,undefined
来源
关键词
NLRP3; Depression; Microglia; IL-1β; Neuroinflammation;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:503 / 514
页数:11
相关论文
共 50 条
  • [31] Celastrol exerts antiarrhythmic effects in chronic heart failure via NLRP3/ Caspase-1/IL-1β signaling pathway
    Tan, Wuping
    Cheng, Siyi
    Qiu, Qinfang
    Huang, Jiaxing
    Xie, Mengjie
    Song, Lingpeng
    Zhou, Zhen
    Wang, Yijun
    Guo, Fuding
    Jin, Xiaoxing
    Li, Zeyan
    Xu, Xiao
    Jiang, Hong
    Zhou, Xiaoya
    BIOMEDICINE & PHARMACOTHERAPY, 2024, 177
  • [32] Inhibiting the NLRP3 Inflammasome Activation with MCC950 Ameliorates Diabetic Encephalopathy in db/db Mice
    Zhai, Yadong
    Meng, Xiangbao
    Ye, Tianyuan
    Xie, Weijie
    Sun, Guibo
    Sun, Xiaobo
    MOLECULES, 2018, 23 (03):
  • [33] The selective NLRP3 inflammasome inhibitor MCC950 alleviates cholestatic liver injury and fibrosis in mice
    Qu, Junwen
    Yuan, Zhiqing
    Wang, Guiyang
    Wang, Xiaopeng
    Li, Kewei
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2019, 70 : 147 - 155
  • [34] Cold Stress Induced Liver Injury of Mice through Activated NLRP3/Caspase-1/GSDMD Pyroptosis Signaling Pathway
    Liu, Yuanyuan
    Xue, Nianyu
    Zhang, Boxi
    Lv, Hongming
    Li, Shize
    BIOMOLECULES, 2022, 12 (07)
  • [35] NLRP3 inflammasome inhibitor MCC950 reduces cerebral ischemia/reperfusion induced neuronal ferroptosis
    Wu, Xiang
    Wang, Bo
    Zhou, Yunfei
    Yang, Zhongbo
    Jiang, Liangchao
    Kou, Zhiyan
    Li, Jiaxi
    Ma, Xudong
    Song, Jinning
    NEUROSCIENCE LETTERS, 2023, 795
  • [36] 平喘颗粒对哮喘小鼠NLRP3/Caspase-1/IL-1β通路的影响
    郅扶旻
    李竹英
    田春燕
    徐洪涛
    现代中西医结合杂志, 2022, 31 (14) : 1906 - 1910
  • [37] Contribution of prgH gene for Salmonella Pullorum to virulence and the expression of NLRP3, Caspase-1 and IL-1β in chickens
    Yin, Junlei
    Cheng, Zhao
    Xu, Zhenyu
    Zhi, Lijuan
    Zhang, Yige
    Yuan, Xinzhong
    Pan, Pengtao
    Sun, Weiwei
    Yu, Tao
    Liu, Tiantian
    MICROBIAL PATHOGENESIS, 2022, 171
  • [38] Inhibiting the NLRP3 Inflammasome With MCC950 Ameliorates Isoflurane-Induced Pyroptosis and Cognitive Impairment in Aged Mice
    Fan, Yunxia
    Du, Liwu
    Fu, Qun
    Zhou, Zhiqiang
    Zhang, Jingyu
    Li, Guomin
    Wu, Jing
    FRONTIERS IN CELLULAR NEUROSCIENCE, 2018, 12
  • [39] MCC950 blocks enhanced interleukin-1β production in patients with NLRP3 low penetrance variants
    Schuh, E.
    Gross, C. J.
    Wagner, D.
    Schlueter, M.
    Gross, O.
    Kuempfel, T.
    CLINICAL IMMUNOLOGY, 2019, 203 : 45 - 52
  • [40] Sweroside ameliorates IMQ-induced psoriasiform inflammation by inhibiting NLRP3/Caspase-1 mediated IL-1β elevation
    Su, Haojie
    Yue, Hongyu
    Liu, Fanlu
    Sun, Yue
    Liang, Shulin
    Zheng, Xuwei
    Zhang, Yating
    Zhang, Junhong
    Wu, Jingjing
    Han, Ling
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2025, 151