Structural basis of West Nile virus neutralization by a therapeutic antibody

被引：0
|
作者：
Grant E. Nybakken
Theodore Oliphant
Syd Johnson
Stephen Burke
Michael S. Diamond
Daved H. Fremont
机构：
[1] Washington University School of Medicine,Departments of Pathology & Immunology
[2] Washington University School of Medicine,Departments of Molecular Microbiology
[3] Washington University School of Medicine,Departments of Biochemistry and Molecular Biophysics
[4] Washington University School of Medicine,Departments of Medicine
[5] MacroGenics,undefined
来源：
Nature | 2005年 / 437卷
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摘要：
West Nile virus is closely related to the human epidemic-causing dengue, yellow fever and Japanese encephalitis viruses. The study of a particularly effective monoclonal antibody, capable of protecting mice from lethal West Nile virus challenge even if administered 5 days after infection, has provided important information on the structural basis of viral neutralization. The work highlights the domain III region of the viral envelope protein as a potential target for both therapeutic antibodies and vaccines.
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页码：764 / 769
页数：5
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