The molecular basis of antibody protection against West Nile Virus

被引：0
|
作者：
Mehlhop, E. [1 ]
Diamond, M. S. [1 ]
机构：
[1] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA
来源：
HUMAN ANTIBODY THERAPEUTICS FOR VIRAL DISEASE | 2008年 / 317卷
关键词：
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
West Nile virus (WNV) infection of mosquitoes, birds, and vertebrates continues to spread to the Western Hemisphere In humans, WNV infects the central nervous system and causes severe disease, primarily in the immunocompromised and elderly In this review we discuss the mechanisms by which antibody controls WNV infection Recent virologic, immunologic, and structural experiments have enhanced our understanding on how antibodies neutralize WNV and protect against disease These advances have significant implications for the development of novel antibody-based therapies and targeted vaccines.
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页码：125 / 153
页数：29
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