Recurrent R-spondin fusions in colon cancer

被引：0
|
作者：
Somasekar Seshagiri
Eric W. Stawiski
Steffen Durinck
Zora Modrusan
Elaine E. Storm
Caitlin B. Conboy
Subhra Chaudhuri
Yinghui Guan
Vasantharajan Janakiraman
Bijay S. Jaiswal
Joseph Guillory
Connie Ha
Gerrit J. P. Dijkgraaf
Jeremy Stinson
Florian Gnad
Melanie A. Huntley
Jeremiah D. Degenhardt
Peter M. Haverty
Richard Bourgon
Weiru Wang
Hartmut Koeppen
Robert Gentleman
Timothy K. Starr
Zemin Zhang
David A. Largaespada
Thomas D. Wu
Frederic J. de Sauvage
机构：
[1] Genentech Inc.,Department of Molecular Biology
[2] 1 DNA Way,Department of Genetics
[3] South San Francisco,Department of Bioinformatics and Computational Biology
[4] California 94080,Department of Structural Biology
[5] USA,Department of Pathology
[6] Cell Biology and Development,Department of Obstetrics
[7] Masonic Cancer Center,undefined
[8] University of Minnesota,undefined
[9] Genentech Inc.,undefined
[10] 1 DNA Way,undefined
[11] South San Francisco,undefined
[12] California 94080,undefined
[13] USA,undefined
[14] Genentech Inc.,undefined
[15] 1 DNA Way,undefined
[16] South San Francisco,undefined
[17] California 94080,undefined
[18] USA,undefined
[19] Genentech Inc.,undefined
[20] 1 DNA Way,undefined
[21] South San Francisco,undefined
[22] California 94080,undefined
[23] USA,undefined
[24] Gynecology & Women’s Health,undefined
[25] Masonic Cancer Center,undefined
[26] University of Minnesota,undefined
来源：
Nature | 2012年 / 488卷
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学科分类号：
摘要：
Exomes, transcriptomes and copy-number alterations in a sample of more than 70 primary human colonic tumours were analysed in an attempt to characterize the genomic landscape; in addition to finding alterations in genes associated with commonly mutated signalling pathways, recurrent gene fusions involving R-spondin family members were also found to occur in approximately 10% of colonic tumours, revealing a potential new therapeutic target.
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收藏
页码：660 / 664
页数：4
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