Recurrent R-spondin fusions in colon cancer

被引：0

作者：

Somasekar Seshagiri

Eric W. Stawiski

Steffen Durinck

Zora Modrusan

Elaine E. Storm

Caitlin B. Conboy

Subhra Chaudhuri

Yinghui Guan

Vasantharajan Janakiraman

Bijay S. Jaiswal

Joseph Guillory

Connie Ha

Gerrit J. P. Dijkgraaf

Jeremy Stinson

Florian Gnad

Melanie A. Huntley

Jeremiah D. Degenhardt

Peter M. Haverty

Richard Bourgon

Weiru Wang

Hartmut Koeppen

Robert Gentleman

Timothy K. Starr

Zemin Zhang

David A. Largaespada

Thomas D. Wu

Frederic J. de Sauvage

机构：

[1] Genentech Inc.,Department of Molecular Biology

[2] 1 DNA Way,Department of Genetics

[3] South San Francisco,Department of Bioinformatics and Computational Biology

[4] California 94080,Department of Structural Biology

[5] USA,Department of Pathology

[6] Cell Biology and Development,Department of Obstetrics

[7] Masonic Cancer Center,undefined

[8] University of Minnesota,undefined

[9] Genentech Inc.,undefined

[10] 1 DNA Way,undefined

[11] South San Francisco,undefined

[12] California 94080,undefined

[13] USA,undefined

[14] Genentech Inc.,undefined

[15] 1 DNA Way,undefined

[16] South San Francisco,undefined

[17] California 94080,undefined

[18] USA,undefined

[19] Genentech Inc.,undefined

[20] 1 DNA Way,undefined

[21] South San Francisco,undefined

[22] California 94080,undefined

[23] USA,undefined

[24] Gynecology & Women’s Health,undefined

[25] Masonic Cancer Center,undefined

[26] University of Minnesota,undefined

来源：

Nature | 2012年 / 488卷

关键词：

D O I：

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中图分类号：

学科分类号：

摘要：

Exomes, transcriptomes and copy-number alterations in a sample of more than 70 primary human colonic tumours were analysed in an attempt to characterize the genomic landscape; in addition to finding alterations in genes associated with commonly mutated signalling pathways, recurrent gene fusions involving R-spondin family members were also found to occur in approximately 10% of colonic tumours, revealing a potential new therapeutic target.

引用

页码：660 / 664

页数：4

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