Quaternary Structure of Nucleoside Diphosphate Kinases

被引：0
|
作者：
Ioan Lascu
Anna Giartosio
Stéphane Ransac
Muriel Erent
机构：
[1] University of Bordeaux-2 and CNRS,Institut de Biochimie et Génétique Cellulaires, UMR 5095
[2] Università La Sapienza,Istituto Pasteur
[3] University of Bordeaux-2 and CNRS,Fondazione Cenci
[4] National Institute for Medical Research,Bolognetti and Dipartimento di Scienze Biochimiche
[5] Mill Hill,Institut de Biochimie et Génétique Cellulaires, UMR 5095
来源：
Journal of Bioenergetics and Biomembranes | 2000年 / 32卷
关键词：
NDP kinase; subunit interaction; quaternary structure; evolution; mixed oligomers; Dictyostelium;
D O I：
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摘要：
Nucleoside (NDP) diphosphate kinases are oligomeric enzymes. Most are hexameric, but somebacterial enzymes are tetrameric. Hexamers and tetramers are constructed by assemblingidentical dimers. The hexameric structure is important for protein stability, as demonstratedby studies with natural mutants (the Killer-of-prune mutant ofDrosophila NDP kinase andthe S120G mutant of the human NDP kinase A in neuroblastomas) and with mutants obtainedby site-directed mutagenesis. It is also essential for enzymic activity. The function of the tetrameric structure is unclear.
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页码：227 / 236
页数：9
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