TGF-β1 Secreted by Hepatocellular Carcinoma Induces the Expression of the Foxp3 Gene and Suppresses Antitumor Immunity in the Tumor Microenvironment

被引：0
|
作者：
Yi Wang
Bin Deng
Wenqing Tang
Taotao Liu
Xizhong Shen
机构：
[1] Fudan University,The Department of Gastroenterology of Zhongshan Hospital
[2] Yangzhou University,The Department of Gastroenterology, Yangzhou First Hospital Affiliated to Yangzhou University
来源：
Digestive Diseases and Sciences | 2013年 / 58卷
关键词：
TGF-β1; Foxp3; IFN-γ; DCs; HCC;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：1644 / 1652
页数：8
相关论文
共 50 条
  • [41] First demonstration of the association between FOXP3 and TGF-β1 in pediatric renal transplant recipients
    Medeiros, M.
    Sharma, V.
    Ding, R.
    Valverde, S.
    Hernandez, A. M.
    Garcia, P.
    Fuentes, Y.
    Suthanthiran, M.
    PEDIATRIC NEPHROLOGY, 2007, 22 (09) : 1583 - 1583
  • [42] TGF-β-Mediated Foxp3 Gene Expression Is Cooperatively Regulated by Stat5, Creb, and AP-1 through CNS2
    Ogawa, Chihiro
    Tone, Yukiko
    Tsuda, Masato
    Peter, Christian
    Waldmann, Herman
    Tone, Masahide
    JOURNAL OF IMMUNOLOGY, 2014, 192 (01): : 475 - 483
  • [43] Cutting edge:: TGF-β-induced expression of Foxp3 in T cells is mediated through inactivation of ERK
    Luo, Xunrong
    Zhang, Qiang
    Liu, Victoria
    Xia, Zhenbiao
    Pothoven, Kathryn L.
    Lee, Chung
    JOURNAL OF IMMUNOLOGY, 2008, 180 (05): : 2757 - 2761
  • [44] FOXP3 gene polymorphism is associated with hepatitis B-related hepatocellular carcinoma in China
    Chen, YanHui
    Zhang, HengHui
    Liao, WeiJia
    Zhou, JinXue
    He, GaiXia
    Xie, XingWang
    Fei, Ran
    Qin, LiLing
    Wei, Lai
    Chen, HongSong
    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2013, 32
  • [45] FOXP3 gene polymorphism is associated with hepatitis B-related hepatocellular carcinoma in China
    YanHui Chen
    HengHui Zhang
    WeiJia Liao
    JinXue Zhou
    GaiXia He
    XingWang Xie
    Ran Fei
    LiLing Qin
    Lai Wei
    HongSong Chen
    Journal of Experimental & Clinical Cancer Research, 32
  • [46] CD44 induces FOXP3 expression and is related with favorable outcome in breast carcinoma
    Sanmartin, Elena
    Ortiz-Martinez, Fernando
    Pomares-Navarro, Eloy
    Garcia-Martinez, Araceli
    Rodrigo-Banos, Montserrat
    Garcia-Escolano, Marta
    Andres, Leire
    Lerma, Enrique
    Aranda, Francisco I.
    Martinez-Peinado, Pascual
    Sempere-Ortells, Jose M.
    Peiro, Gloria
    VIRCHOWS ARCHIV, 2017, 470 (01) : 81 - 90
  • [47] TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells
    Marie, JC
    Letterio, JJ
    Gavin, M
    Rudensky, AY
    JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (07): : 1061 - 1067
  • [48] CD44 induces FOXP3 expression and is related with favorable outcome in breast carcinoma
    Elena Sanmartín
    Fernando Ortiz-Martínez
    Eloy Pomares-Navarro
    Araceli García-Martínez
    Montserrat Rodrigo-Baños
    Marta García-Escolano
    Leire Andrés
    Enrique Lerma
    Francisco I. Aranda
    Pascual Martínez-Peinado
    José M. Sempere-Ortells
    Gloria Peiró
    Virchows Archiv, 2017, 470 : 81 - 90
  • [49] FOXP3 Is a HCC suppressor gene and Acts through regulating the TGF-β/Smad2/3 signaling pathway
    Shi, Jie-Yi
    Ma, Li-Jie
    Zhang, Ji-Wei
    Duan, Meng
    Ding, Zhen-Bin
    Yang, Liu-Xiao
    Cao, Ya
    Zhou, Jian
    Fan, Jia
    Zhang, Xiaoming
    Zhao, Ying-Jun
    Wang, Xiao-Ying
    Gao, Qiang
    BMC CANCER, 2017, 17
  • [50] FOXP3 Is a HCC suppressor gene and Acts through regulating the TGF-β/Smad2/3 signaling pathway
    Jie-Yi Shi
    Li-Jie Ma
    Ji-Wei Zhang
    Meng Duan
    Zhen-Bin Ding
    Liu-Xiao Yang
    Ya Cao
    Jian Zhou
    Jia Fan
    Xiaoming Zhang
    Ying-Jun Zhao
    Xiao-Ying Wang
    Qiang Gao
    BMC Cancer, 17
12345