Argininosuccinate synthase 1 suppresses tumor progression through activation of PERK/eIF2α/ATF4/CHOP axis in hepatocellular carcinoma

被引：0
|
作者：
Sanghwa Kim
Minji Lee
Yeonhwa Song
Su-Yeon Lee
Inhee Choi
I-Seul Park
Jiho Kim
Jin-sun Kim
Kang mo Kim
Haeng Ran Seo
机构：
[1] Institut Pasteur Korea,Cancer Biology Research Laboratory
[2] Institut Pasteur Korea,Medicinal Chemistry
[3] Institut Pasteur Korea,Screening Discovery Platform
[4] Asan Liver Center,Department of Gastroenterology
[5] Asan Medical Center,undefined
[6] University of Ulsan College of Medicine,undefined
来源：
Journal of Experimental & Clinical Cancer Research | / 40卷
关键词：
Hepatocellular carcinoma (HCC); Argininosuccinate synthase 1(ASS1); Endoplasmic reticulum (ER) stress; Spheroids; C/EBP homologous protein (CHOP);
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [21] The Effects of Puerarin on Autophagy Through Regulating of the PERK/eIF2α/ATF4 Signaling Pathway In fluences Renal Function in Diabetic Nephropathy
    Xu, Xiaohui
    Chen, Biao
    Huang, Qichun
    Wu, Yani
    Liang, Tao
    DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY, 2020, 13 : 2583 - 2592
  • [22] The oncogene ERH regulates the eIF2α-ATF4/CHOP pathway to affect tumorigenesis in bladder cancer cells
    Pang, Kun
    Chen, Bo
    Han, Conghui
    INTERNATIONAL JOURNAL OF UROLOGY, 2020, 27 : 48 - 48
  • [23] Isovalerylspiramycin I suppresses small cell lung cancer proliferation via ATR/CHK1 mediated DNA damage response and PERK/eIF2α/ATF4/CHOP mediated ER stress
    Xu, Yongle
    Gu, Xiaohua
    Shan, Shan
    Liu, Zeyu
    Wang, Shaoyang
    Zhang, Jingyuan
    Lei, Yuqiong
    Zhong, Cheng
    Zheng, Qi
    Ren, Tao
    Li, Zhanxia
    BIOCHEMICAL PHARMACOLOGY, 2024, 230
  • [24] Vortioxetine mitigates neuronal damage by restricting PERK/eIF2α/ATF4/CHOP signaling pathway in rats subjected to focal cerebral ischemia-reperfusion
    Emam, Amr M.
    Saad, Muhammad A.
    Ahmed, Naglaa A.
    Zaki, Hala F.
    LIFE SCIENCES, 2021, 283
  • [25] 洛铂通过PERK/eIF2α/ATF4/CHOP信号通路调节肺癌细胞A549的作用机制
    童凯
    罗红兰
    世界临床药物, 2023, 44 (08) : 805 - 812
  • [26] Optineurin downregulation is associated with activation of PERK/EIF2A/ATF4 in pancreatic cancer cells
    Ali, D. M.
    Ansari, S.
    Berger, M.
    ONCOLOGY RESEARCH AND TREATMENT, 2018, 41 : 63 - 64
  • [27] Edaravone protects against glutamate-induced PERK/EIF2α/ATF4 integrated stress response and activation of caspase-12
    Fan, Jin
    Long, Hao
    Li, Yiming
    Liu, Yuwen
    Zhou, Wei
    Li, Qingqing
    Yin, Guoyong
    Zhang, Ning
    Cai, Weihua
    BRAIN RESEARCH, 2013, 1519 : 1 - 8
  • [28] Activation of the eIF2α/ATF4 axis drives triple-negative breast cancer radioresistance by promoting glutathione biosynthesis
    Bai, Xupeng
    Ni, Jie
    Beretov, Julia
    Wasinger, Valerie C.
    Wang, Shanping
    Zhu, Ying
    Graham, Peter
    Li, Yong
    REDOX BIOLOGY, 2021, 43
  • [29] Brain-Specific Disruption of the eIF2α Kinase PERK Decreases ATF4 Expression and Impairs Behavioral Flexibility
    Trinh, Mimi A.
    Kaphzan, Hanoch
    Wek, Ronald C.
    Pierre, Philippe
    Cavener, Douglas R.
    Klann, Eric
    CELL REPORTS, 2012, 1 (06): : 676 - 688
  • [30] Short-Term Fasting Increases PEPCK Expression and Gluconeogenesis through Activation of the EiF2α/ATF4 Pathway
    Junqueira, Jose Claudio N.
    Ogawa, Cindy M.
    Kinote, Andrezza
    Sollon, Carolina
    Araujo, Thiago M.
    Bordin, Silvana
    Velloso, Licio A.
    Anhe, Gabriel F.
    DIABETES, 2011, 60 : A685 - A685
12345