Engineering 3D genome organization

被引：0
|
作者：
Haifeng Wang
Mengting Han
Lei S. Qi
机构：
[1] Stanford University,Department of Bioengineering
[2] Stanford University,Department of Chemical and Systems Biology
[3] Stanford University,ChEM
来源：
Nature Reviews Genetics | 2021年 / 22卷
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D O I：
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学科分类号：
摘要：
Cancers and developmental disorders are associated with alterations in the 3D genome architecture in space and time (the fourth dimension). Mammalian 3D genome organization is complex and dynamic and plays an essential role in regulating gene expression and cellular function. To study the causal relationship between genome function and its spatio-temporal organization in the nucleus, new technologies for engineering and manipulating the 3D organization of the genome have been developed. In particular, CRISPR–Cas technologies allow programmable manipulation at specific genomic loci, enabling unparalleled opportunities in this emerging field of 3D genome engineering. We review advances in mammalian 3D genome engineering with a focus on recent manipulative technologies using CRISPR–Cas and related technologies.
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页码：343 / 360
页数：17
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