Erythroblastic sarcoma transformation from a chronic myeloid neoplasm with FGFR1 rearrangement presenting as a pleural effusion: a case report

被引：0

作者：

Joanna C. Dalland

Alexandra Higgins

Horatiu Olteanu

Kaaren K. Reichard

Reid Meyer

Gregory E. Otteson

Patricia T. Greipp

Rebecca L. King

机构：

[1] Department of Laboratory Medicine and Pathology,

[2] Division of Hematopathology,undefined

[3] Mayo Clinic,undefined

[4] Department of Internal Medicine,undefined

[5] Division of Hematology,undefined

[6] Mayo Clinic,undefined

[7] Department of Laboratory Medicine and Pathology,undefined

[8] Division of Laboratory Genetics and Genomics,undefined

[9] Mayo Clinic,undefined

来源：

Journal of Hematopathology | 2021年 / 14卷

关键词：

rearrangement; Erythroblastic sarcoma; Pure erythroid leukemia; Running title: Erythroblastic sarcoma transformation from chronic myeloid neoplasm with ; rearrangement.;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Myeloid/lymphoid neoplasms with FGFR1 rearrangement (MLN-FGFR1) comprise a heterogeneous group of neoplasms that can present as a myeloproliferative neoplasm, a myelodysplastic/myeloproliferative neoplasm, acute myeloid leukemia, T or B lymphoblastic leukemia/lymphoma, or mixed phenotype acute leukemia. The overall outcome of these neoplasms is poor, and these patients often show cytogenetic evolution with gain of additional chromosomal abnormalities leading to transformation to acute leukemia. Pure erythroid leukemia and erythroblastic sarcoma evolving from a preexisting chronic myeloid neoplasm have rarely been described; however, this has not been reported in MLN-FGFR1. Herein we describe a biopsy-proven chronic myeloid neoplasm with FGFR1 rearrangement with transformation to erythroblastic sarcoma presenting as a pleural effusion.

引用

页码：157 / 162

页数：5

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