Synthesis and nucleophilic dearomatization of highly electrophilic [1,2,5]selenadiazolo[3,4-b]pyridines

被引：0
|
作者：
V. V. Ivanova
A. K. Fedorenko
A. M. Starosotnikov
M. A. Bastrakov
机构：
[1] Russian Academy of Sciences,N. D. Zelinsky Institute of Organic Chemistry
来源：
Russian Chemical Bulletin | 2022年 / 71卷
关键词：
fused pyridines; C-nucleophiles; nucleophilic addition; 1,4-dihydropyridines; dearomatization; [1,2,5]selenadiazoles;
D O I：
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学科分类号：
摘要：
A number of [1,2,5]selenadiazolo[3,4-b]pyridines were synthesized on the basis of readily available 5-R-2,3-diaminopyridines. It was found that these compounds can be involved into the reactions with C-nucleophiles (1,3-dicarbonyl compounds, indoles) under mild conditions, in some cases with no base required. As a result, stable products of nucleophilic addition to the pyridine ring, 1,4-dihydropyridines fused with selenadiazole ring, were formed in up to 94% yield.
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页码：1826 / 1829
页数：3
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