Synthesis and biological evaluation of novel triazole substituted pyrazolyl-methylenehydrazinyl-5-arylidene thiazolidinone derivatives as antibacterial and cytotoxic agents

被引：0
|
作者：
Vinay Pogaku
Ravi Kumar Eslavath
G. Dayakar
Surya S. Singh
Srinivas Basavoju
机构：
[1] National Institute of Technology,Department of Chemistry
[2] Osmania University,Department of Biochemistry
[3] Kakatiya University,Department of Biotechnology
来源：
Research on Chemical Intermediates | 2017年 / 43卷
关键词：
3-Methyl-1-phenyl-1; -pyrazol-5(4; )-one; 1; -1,2,4-triazole; 1; -benzo[d][1,2,3]triazole; Pyrazolyl-methylenehydrazinyl-5-arylidene thiazolidinones; Antibacterial; Cytotoxic activity;
D O I：
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中图分类号：
学科分类号：
摘要：
Novel triazole substituted pyrazolyl-methylenehydrazinyl-5-arylidene thiazolidinone derivatives 6a–n and 7a–l were synthesized and characterized by Fourier transform infrared, 1H and 13C nuclear magnetic resonance, mass spectrometry and elemental (CHN) analysis. The in vitro antibacterial (6a–n and 7a–l) and cytotoxic (6a–n) activities were evaluated for these compounds. The results revealed that the compounds 6b, 6i, 6k, 7b, 7h displayed good antibacterial activity. The compounds 6c (IC50 = 5.4 μM), 6l (IC50 = 6.3 μM) and 6f (IC50 = 9.85 μM) were effective for inhibition of human breast cancer cell line MCF-7. Similarly, the compounds 6b (IC50 = 8.7 μM) and 6c (IC50 = 9.06 μM) were shown to have effective inhibition on human cervical cancer cell line Hela.
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页码：6079 / 6098
页数：19
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