Structural basis of recognition of interferon-α receptor by tyrosine kinase 2

被引：0
|
作者：
Heidi J A Wallweber
Christine Tam
Yvonne Franke
Melissa A Starovasnik
Patrick J Lupardus
机构：
[1] Genentech,Department of Structural Biology
来源：
Nature Structural & Molecular Biology | 2014年 / 21卷
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摘要：
How the four JAK kinases discriminate between different cytokine receptors is not well understood. The first crystal structure of a JAK kinase (TYK2) bound to a cytokine receptor (INFAR1) now exposes a multipoint interaction mode that involves an atypical phosphoindependent interaction between TYK2's SH2 domain and INFAR1's conserved box2 motif.
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页码：443 / 448
页数：5
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