Family-based association tests for quantitative traits using pooled DNA

被引：0
|
作者：
Joel S Bader
Pak Sham
机构：
[1] CuraGen Corporation,Department of Psychological Medicine
[2] Institute of Psychiatry,undefined
[3] King's College,undefined
[4] Social,undefined
[5] Genetic and Developmental Psychiatry Research Centre,undefined
[6] Institute of Psychiatry,undefined
[7] King's College,undefined
来源：
European Journal of Human Genetics | 2002年 / 10卷
关键词：
association; linkage; quantitative trait locus (QTL); single-nucleotide polymorphism (SNP); DNA pooling; genotyping;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Interest in whole-genome QTL mapping has spurred efforts to reduce the cost of studies now based primarily on individual genotyping. Pooled DNA tests are a possible solution, and understanding how measurement error affects test power could assist in study design. Here we describe pooled tests explicitly optimised for measurement error, including family-based tests robust to population stratification. Our results suggest that pooled DNA whole-genome screens may be feasible with current instruments.
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页码：870 / 878
页数：8
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