Family-based association tests for quantitative traits using pooled DNA

被引：0
|
作者：
Joel S Bader
Pak Sham
机构：
[1] CuraGen Corporation,Department of Psychological Medicine
[2] Institute of Psychiatry,undefined
[3] King's College,undefined
[4] Social,undefined
[5] Genetic and Developmental Psychiatry Research Centre,undefined
[6] Institute of Psychiatry,undefined
[7] King's College,undefined
来源：
European Journal of Human Genetics | 2002年 / 10卷
关键词：
association; linkage; quantitative trait locus (QTL); single-nucleotide polymorphism (SNP); DNA pooling; genotyping;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Interest in whole-genome QTL mapping has spurred efforts to reduce the cost of studies now based primarily on individual genotyping. Pooled DNA tests are a possible solution, and understanding how measurement error affects test power could assist in study design. Here we describe pooled tests explicitly optimised for measurement error, including family-based tests robust to population stratification. Our results suggest that pooled DNA whole-genome screens may be feasible with current instruments.
引用
收藏
页码：870 / 878
页数：8
相关论文
共 50 条
  • [1] Family-based association tests for quantitative traits using pooled DNA
    Bader, JS
    Sham, P
    [J]. EUROPEAN JOURNAL OF HUMAN GENETICS, 2002, 10 (12) : 870 - 878
  • [2] Family-based association tests for different family structures using pooled DNA
    Zou, GH
    Zhao, HY
    [J]. ANNALS OF HUMAN GENETICS, 2005, 69 : 429 - 442
  • [3] Family-Based Bivariate Association Tests for Quantitative Traits
    Zhang, Lei
    Bonham, Aaron J.
    Li, Jian
    Pei, Yu-Fang
    Chen, Jie
    Papasian, Christopher J.
    Deng, Hong-Wen
    [J]. PLOS ONE, 2009, 4 (12):
  • [4] A comparison of family-based association tests for quantitative traits
    不详
    [J]. GENETIC EPIDEMIOLOGY, 2004, 27 (03) : 264 - 265
  • [5] Singular value decomposition in permutations for family-based association tests for quantitative traits
    Tayo, Bamidele O.
    Cooper, Richard S.
    [J]. GENETIC EPIDEMIOLOGY, 2015, 39 (07) : 585 - 585
  • [6] Combining Multi-marker Association Tests for Quantitative Traits in the Family-based Association Study
    Dai, Yilin
    Dong, Jianping
    Jiang, Renfang
    Guo, Ling
    [J]. GENETIC EPIDEMIOLOGY, 2010, 34 (08) : 961 - 961
  • [7] EMK: A novel program for family-based allelic and genotypic association tests on quantitative traits
    Li, Y. W.
    Martin, E. R.
    Li, Y. J.
    [J]. ANNALS OF HUMAN GENETICS, 2008, 72 : 388 - 396
  • [8] Power and design considerations for a general class of family-based association tests: Quantitative traits
    Lange, C
    DeMeo, DL
    Laird, NM
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2002, 71 (06) : 1330 - 1341
  • [9] Family-based association tests for qualitative and quantitative traits using single-nucleotide polymorphism and microsatellite data
    Wilk, JB
    Volcjak, JS
    Myers, RH
    Maher, NE
    Knowlton, BA
    Heard-Costa, NL
    Demissie, S
    Cupples, LA
    DeStefano, AL
    [J]. GENETIC EPIDEMIOLOGY, 2001, 21 : S364 - S369
  • [10] Family-based association tests for ordinal traits adjusting for covariates
    Wang, Xueqin
    Ye, Yuanqing
    Zhang, Heping
    [J]. GENETIC EPIDEMIOLOGY, 2006, 30 (08) : 728 - 736
12345