Acquired pseudocholinesterase deficiency after high-dose cyclophosphamide

被引：0
|
作者：
V Koseoglu
J Chiang
KW Chan
机构：
[1] University of Texas MD Anderson Cancer,Division of Pediatrics
[2] University of Texas MD Anderson Cancer,Division of Anesthesiology and Critical Care
来源：
Bone Marrow Transplantation | 1999年 / 24卷
关键词：
cyclophosphamide; prolonged apnea; pseudocholinesterase; succinylcholine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Succinylcholine, a depolarizing neuromuscular blocking agent used in anesthesia is hydrolyzed in the plasma by the enzyme pseudocholinesterase (PSC). Conditions associated with reduced PSC activity lead to sustained action of succinylcholine and result in prolonged apnea. Cyclophosphamide is an inhibitor of PSC and its suppressive effect may be dose-dependent. We report a case of severe PSC deficiency after high-dose cyclophosphamide at 7 g/m2. The patient received succinylcholine during anesthesia 9 h after chemotherapy and developed prolonged apnea. This case highlights the potential risk of drug-induced PSC deficiency and cautions the use of depolarizing muscular relaxants soon after high-dose cyclophosphamide.
引用
收藏
页码：1367 / 1368
页数：1
相关论文
共 50 条
  • [1] Acquired pseudocholinesterase deficiency after high-dose cyclophosphamide
    Koseoglu, V
    Chiang, J
    Chan, KW
    BONE MARROW TRANSPLANTATION, 1999, 24 (12) : 1367 - 1368
  • [2] ACQUIRED EPISODIC COMPLETE HEARTBLOCK AFTER HIGH-DOSE CHEMOTHERAPY WITH CYCLOPHOSPHAMIDE AND THIOTEPA
    RAMIREDDY, K
    KANE, KM
    ADHAR, GC
    AMERICAN HEART JOURNAL, 1994, 127 (03) : 701 - 704
  • [3] THE PHARMACOKINETICS OF HIGH-DOSE CYCLOPHOSPHAMIDE AND HIGH-DOSE ETOPOSIDE
    CUNNINGHAM, D
    CUMMINGS, J
    BLACKIE, RB
    MCTAGGART, L
    BANHAM, SW
    KAYE, SB
    SOUKOP, M
    MEDICAL ONCOLOGY AND TUMOR PHARMACOTHERAPY, 1988, 5 (02): : 117 - 123
  • [4] THE COURSE OF NAUSEA AND VOMITING AFTER HIGH-DOSE CYCLOPHOSPHAMIDE
    FETTING, JH
    GROCHOW, LB
    FOLSTEIN, MF
    ETTINGER, DS
    COLVIN, M
    CANCER TREATMENT REPORTS, 1982, 66 (07): : 1487 - 1493
  • [5] ANTIEMETICS FOR HIGH-DOSE CYCLOPHOSPHAMIDE
    KEARNEY, PJ
    BRITISH MEDICAL JOURNAL, 1975, 1 (5949): : 95 - 96
  • [6] RAPID DEVELOPMENT OF ENHANCED CLEARANCE AFTER HIGH-DOSE CYCLOPHOSPHAMIDE
    MOORE, MJ
    HARDY, RW
    THIESSEN, JJ
    SOLDIN, SJ
    ERLICHMAN, C
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 1988, 44 (06) : 622 - 628
  • [7] A Rare Case of Acquired Pseudocholinesterase Deficiency
    Nagasunder, A.
    Cardenas, J.
    Musenze, J.
    Szambelan, E.
    DeSilva, E.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2020, 201
  • [8] High-dose cyclophosphamide for autoimmunity and alloimmunity
    Brodsky, Robert A.
    IMMUNOLOGIC RESEARCH, 2010, 47 (1-3) : 179 - 184
  • [9] High-dose cyclophosphamide compared with antithymocyte globulin for treatment of acquired severe aplastic anemia
    Zhang, Fengkui
    Zhang, Li
    Jing, Liping
    Zhou, Kang
    Wang, Huijun
    Peng, Guangxin
    Li, Yang
    Li, Yuan
    Li, Jianping
    Ye, Lei
    Shi, Lihui
    Fan, Huihui
    Zhao, Xin
    Chu, Yulin
    Hao, Yushu
    Wang, Jianxiang
    EXPERIMENTAL HEMATOLOGY, 2013, 41 (04) : 328 - 334
  • [10] High-dose cyclophosphamide for autoimmunity and alloimmunity
    Robert A. Brodsky
    Immunologic Research, 2010, 47 : 179 - 184
12345