High-dose cyclophosphamide for autoimmunity and alloimmunity

被引：0
|
作者：
Robert A. Brodsky
机构：
[1] Johns Hopkins University School of Medicine,The Division of Hematology
来源：
Immunologic Research | 2010年 / 47卷
关键词：
Cyclophosphamide; Autoimmunity; Bone marrow transplantation; Aplastic anemia;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
High-dose cyclophosphamide (high-CY) is a potent immunosuppressive regimen that is increasingly used to mitigate both autoimmune and alloimmune conditions. Differential expression of aldehyde dehydrogenase between hematopoietic stem cells and lymphocytes accounts for the differential sensitivity of these cells to high-CY and explains why this regimen is immunosuppressive but not myeloablative. This article describes the clinical translation of high-CY for the treatment of autoimmune and alloimmune conditions.
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页码：179 / 184
页数：5
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