Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia

被引：0

作者：

Panagiotis Ntziachristos

Aristotelis Tsirigos

G. Grant Welstead

Thomas Trimarchi

Sofia Bakogianni

Luyao Xu

Evangelia Loizou

Linda Holmfeldt

Alexandros Strikoudis

Bryan King

Jasper Mullenders

Jared Becksfort

Jelena Nedjic

Elisabeth Paietta

Martin S. Tallman

Jacob M. Rowe

Giovanni Tonon

Takashi Satoh

Laurens Kruidenier

Rab Prinjha

Shizuo Akira

Pieter Van Vlierberghe

Adolfo A. Ferrando

Rudolf Jaenisch

Charles G. Mullighan

Iannis Aifantis

机构：

[1] NYU School of Medicine,Howard Hughes Medical Institute and Department of Pathology

[2] NYU Cancer Institute and Helen L. and Martin S. Kimmel Center for Stem Cell Biology,Department of Biology

[3] NYU School of Medicine,Department of Pathology

[4] Center for Health Informatics and Bioinformatics,Department of Computational Biology

[5] NYU School of Medicine,Division of Molecular Oncology

[6] Whitehead Institute for Biomedical Research,Department of Host Defense

[7] Massachusetts Institute of Technology,Department of Pathology

[8] Institute for Cancer Genetics,Department of Pediatrics

[9] Columbia University Medical Center,undefined

[10] St. Jude Children’s Research Hospital,undefined

[11] St. Jude Children’s Research Hospital,undefined

[12] Montefiore Medical Center North,undefined

[13] Bronx,undefined

[14] Memorial Sloan Kettering Cancer Center,undefined

[15] Technion,undefined

[16] Israel Institute of Technology,undefined

[17] Shaare Zedek Medical Center,undefined

[18] Functional Genomics of Cancer Unit,undefined

[19] Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute,undefined

[20] 20132 Milan,undefined

[21] Italy,undefined

[22] Laboratory of Host Defense,undefined

[23] WPI Immunology Frontier Research Center (WPI IFReC),undefined

[24] Osaka University,undefined

[25] 3-1 Yamada-oka,undefined

[26] Suita,undefined

[27] Osaka 565-0871,undefined

[28] Japan,undefined

[29] Research Institute for Microbial Diseases (RIMD),undefined

[30] Osaka University,undefined

[31] 3-1Yamada-oka,undefined

[32] Suita,undefined

[33] Osaka 565-0871,undefined

[34] Japan,undefined

[35] Epinova DPU,undefined

[36] Immuno-Inflammation Therapy Area,undefined

[37] GlaxoSmithKline R&D,undefined

[38] Medicines Research Centre,undefined

[39] GunnelsWood Road,undefined

[40] Stevenage SG1 2NY,undefined

[41] UK,undefined

[42] Center for Medical Genetics,undefined

[43] Ghent University Hospital,undefined

[44] 9000 Ghent,undefined

[45] Belgium,undefined

[46] Columbia University Medical Center,undefined

[47] Columbia University Medical Center,undefined

[48] Present address: Editas Medicine,undefined

[49] Cambridge,undefined

[50] Massachusetts 02142,undefined

来源：

Nature | 2014年 / 514卷

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摘要：

T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a poor prognosis and no available targeted therapies; now two histone H3 lysine 27 demethylases, JMJD3 and UTX, are shown to have contrasting roles in human T-ALL cells and a mouse model of the disease, and a small molecule demethylase inhibitor is found to inhibit the growth of T-ALL cell lines, introducing a potential therapeutic avenue for acute leukaemia.

引用

页码：513 / 517

页数：4

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