Negative regulation of TGF-β signaling in development

被引：0
|
作者：
Ye Guang CHEN
An Ming MENG
机构：
[1] The State Key Laboratory of Biomembrane and Membrane Biotechnology,Department of Biological Sciences and Biotechnology
[2] Tsinghua University,undefined
来源：
Cell Research | 2004年 / 14卷
关键词：
TGF-β; BMP; Nodal; Activin; antagonist; development; negative regulation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The TGF-β superfamily members have important roles in controlling patterning and tissue formation in both invertebrates and vertebrates. Two types of signal transducers, receptors and Smads, mediate the signaling to regulate expression of their target genes. Despite of the relatively simple signal transduction pathway, many modulators have been found to contribute to a tight regulation of this pathway in a variety of mechanisms. This article reviews the negative regulation of TGF-β signaling with focus on its roles in vertebrate development.
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页码：441 / 449
页数：8
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