Antioxidant Activity of Phenolic Metabolites from Marine Sponges

被引:0
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作者
N. K. Utkina
A. E. Makarchenko
O. V. Shchelokova
M. V. Virovaya
机构
[1] Russian Academy of Sciences,Pacific Institute of Bioorganic Chemistry, Far
[2] Far-East State University,East Division
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关键词
marine metabolites; sesquiterpenequinones; terpenoid phenols; antioxidants; marine sponges;
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摘要
The marine-sponge metabolitesilimaquinone (1), isospongiaquinone(2),puupenone(3), 15-methoxypuupenol (4), 2-methyl-2-pentaprenyl-6-hydroxychromene (5), (+)-curcuphenol (6), (+)-curcudiol (7), and semisynthetic sesquiterpenequinones (8-11) were investigated for ability to trap the free radical 1,1,-diphenyl-2-picrylhydrazyl (DPPH), to inhibit Fe2+ /ascorbate-induced oxidation of lipidsfromrat-brain homogenate, and to inhibit oxidation of linseed oil. It was shown that metabolites 3-5 were the most active antioxidants.
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页码:373 / 377
页数:4
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