Synthesis of novel 2'-aryl-4'-hydroxy-4',5,5',6-tetrahydro- 2'H,8H-spiro[indolizine-7,3'-thiophen]-8-one derivatives via sulfa-Michael/aldol cascade reactions

被引：0
|
作者：
Yulin Huang
Guihua Tang
Demin Ren
Ju-Lan Zeng
Xiaofang Li
机构：
[1] Hunan University of Science and Technology,Key Laboratory of Theoretical Organic Chemistry and Functional Molecules, Ministry of Education, School of Chemistry and Chemical Engineering
[2] Changsha University of Science and Technology,School of Chemistry and Food Engineering
来源：
Chemistry of Heterocyclic Compounds | 2020年 / 56卷
关键词：
1,4-dithiane-2,5-diol; 6,7-dihydroindolizin-8(5; )-one; sulfa-Michael/aldol cascade reaction; spiro heterocycle;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The sulfa-Michael/aldol cascade reaction of (E)-7-arylidene-6,7-dihydroindolizin-8(5H)-ones and 1,4-dithiane-2,5-diol afforded novel 2'-aryl-4'-hydroxy-4',5,5',6-tetrahydro-2'H,8H-spiro[indolizine-7,3'-thiophen]-8-ones in low to moderate yields. The structures of all products were characterized thoroughly by NMR, IR, HRMS, together with X-ray crystallographic analysis.
引用
收藏
页码：42 / 46
页数：4
相关论文
共 50 条
  • [21] Synthesis of 1-aryl-2-methyl-3-ethoxycarbonyl-1,4,5,6 - tetrahydro-4(1H)-pyridones and their derivatives
    Mickevicius, V.
    Bylinskaite, J.
    Tetrahedron Letters, 37 (20):
  • [22] A NOVEL SYNTHESIS OF 5-ARYL-AND 4,5-DISUBSTITUTED 3-METHOXYFURAN-2(5H)-ONES AND SOME OF THEIR 5,5'-BI DERIVATIVES
    Xu-Sheng ZHANG Jun ZHU Pang ZHANG Department of Chemistry
    Chinese Chemical Letters, 1992, (12) : 955 - 958
  • [23] 6,7,8,9-Tetrahydro-2H-1,2,4-triazolo[4,3-a]azepin-3(5H)-one
    Yu, GS
    Xu, HZ
    Zhang, X
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2006, 62 : O711 - O712
  • [24] Synthesis and antimicrobial activity of 6,7,8,9-Tetrahydro-5(H)-5-nitrophenylthiazolo[2,3-b]-quinazoline-3(2H)-one derivatives
    Kumar, P. Praveen
    Prasad, Y. Rajendra
    Kumar, N. R.
    Sridhar, S.
    ASIAN JOURNAL OF CHEMISTRY, 2008, 20 (07) : 5161 - 5165
  • [25] THE SYNTHESIS OF [1',3'-H-3]4-(4'-AZIDO-5',6',7',8'-TETRAHYDRO-5',5',8',8'-TETRAMETHYL-2'-ANTHRACENYL)BENZOIC ACID AS A PROBE OF THE RETINOIC ACID RECEPTOR
    DAWSON, MI
    HOBBS, PD
    DORSKY, A
    MORIMOTO, H
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 1990, 28 (01): : 89 - 98
  • [26] SYNTHESIS OF [1',3',4'-H-3(3)]4-(5',6',7',8',-TETRAHYDRO-5',5',8',8'-TETRAMETHYL-2'-ANTHRACENYL)BENZOIC ACID FOR BINDING-STUDIES OF RETINOIC ACID RECEPTORS
    DAWSON, MI
    HOBBS, PD
    RHEE, SW
    MORIMOTO, H
    WILLIAMS, PG
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 1993, 33 (07): : 633 - 637
  • [27] Synthesis and structure of 3,4,5,6-tetrahydro-8-hydroxy-1H,6H-naphtho[1,2-h]pyrrolo[2,1-e][1,3,6,2]dioxazaboronin-6-one dimer
    Gawdzik, B
    Iwanek, W
    Bak, J
    Wozniak, K
    INORGANIC CHEMISTRY COMMUNICATIONS, 2005, 8 (10) : 928 - 931
  • [28] A facile one-pot synthesis of novel 1-substituted 2-(8-hydroxyquinolin-5-yl)-1,5,6,7-tetrahydro-6,6-dimethyl-4H-indol-4-one derivatives
    Abdel-Mohsen, Shawkat
    El-Emary, Talaat
    ARKIVOC, 2016, : 184 - 192
  • [29] NOVEL MAST CELL-STABILISING AMINE DERIVATIVES OF 3,4 DIHYDRONAPHTHALEN-1(2H)-ONE AND 6,7,8,9-TETRAHYDRO-5H-BENZO[7]ANNULEN-5-ONE
    Barlow, J. W.
    Zhang, T.
    Woods, O.
    Walsh, J. J.
    INFLAMMATION RESEARCH, 2012, 61 : S69 - S70
  • [30] NOVEL MAST CELL-STABILISING ALCOHOL DERIVATIVES OF 3,4 DIHYDRONAPHTHALEN-1(2H)-ONE and 6,7,8,9-TETRAHYDRO-5H-BENZO[7]ANNULEN-5-ONE
    Finn, D. F.
    Zhang, T.
    Woods, O.
    Walsh, J. J.
    INFLAMMATION RESEARCH, 2015, 64 : S15 - S15
12345