The molecular mechanism of human stem cell-derived extracellular vesicles in retinal repair and regeneration

被引：0
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作者：
Mei Yang
Guang-hua Peng
机构：
[1] Basic Medical College,Laboratory of Visual Cell Differentiation and Regulation
[2] Zhengzhou University,Department of Pathophysiology, Basic Medical College
[3] Zhengzhou University,undefined
来源：
Stem Cell Research & Therapy | / 14卷
关键词：
Retina; Repair; Regeneration; Stem cell; Extracellular vesicle; Therapy;
D O I：
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学科分类号：
摘要：
Extracellular vesicles (EVs), including microvesicles (MVs) and exosomes, play a critical role in metabolic regulation and intracellular communication. Stem cell-derived EVs are considered to have the potential for regeneration, like stem cells, while simultaneously avoiding the risk of immune rejection or tumour formation. The therapeutic effect of stem cell-derived EVs has been proven in many diseases. However, the molecular mechanism of stem cell-derived EVs in retinal repair and regeneration has not been fully clarified. In this review, we described the biological characteristics of stem cell-derived EVs, summarized the current research on stem cell-derived EV treatment in retinal repair and regeneration, and discussed the potential and challenges of stem cell-derived EVs in translational medicine.
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