Gluten ataxia

被引:0
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作者
Marios Hadjivassiliou
David S. Sanders
Nicola Woodroofe
Claire Williamson
Richard A. Grünewald
机构
[1] The Royal Hallamshire Hospital,Department of Neurology
[2] Sheffield Teaching Hospitals NHS Trust,Department of Gastroenterology
[3] The Royal Hallamshire Hospital,Department of Biomedical Science
[4] Sheffield Teaching Hospitals NHS Trust,Department of Neurology
[5] Sheffield Hallam University,undefined
[6] The Royal Hallamshire Hospital,undefined
来源
The Cerebellum | 2008年 / 7卷
关键词
Gluten ataxia; cerebellum;
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学科分类号
摘要
Gluten ataxia is an immune-mediated disease triggered by the ingestion of gluten in genetically susceptible individuals. It should be considered in the differential diagnosis of all patients with idiopathic sporadic ataxia. Early diagnosis and treatment with a gluten free diet can improve ataxia and prevent its progression. Readily available and sensitive markers of gluten ataxia include antigliadin antibodies. IgA deposits against TG2 in the small bowel and at extraintestinal sites are proving to be additional reliable and perhaps more specific markers of the whole spectrum of gluten sensitivity. They may also hold the key to its pathogenesis.
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