Biodegradable Cable-Tie Rapamycin-eluting Stents

被引:0
|
作者
Cheng-Hung Lee
Ming-Jer Hsieh
Shang-Hung Chang
Chang-Lin Chiang
Ching-Lung Fan
Shih-Jung Liu
Wei-Jan Chen
Chao-Jan Wang
Ming-Yi Hsu
Kuo-Chun Hung
Chung-Chuan Chou
Po-Cheng Chang
机构
[1] Chang Gung University College of Medicine,Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital
[2] Chang Gung University,Linkou
[3] Chang Gung Memorial Hospital-Linkou,Department of Mechanical Engineering
[4] Chang Gung Memorial Hospital-Linkou,Department of Orthopedic Surgery
来源
Scientific Reports | / 7卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
“Cable-tie” type biodegradable stents with drug-eluting nanofiber were developed to treat rabbit denuded arteries in this study. Biodegradable stents were fabricated using poly-L-lactide film following being cut and rolled into a cable-tie type stent. Additionally, drug-eluting biodegradable nanofiber tubes were electrospun from a solution containing poly (lactic-co-glycolic acid), rapamycin, and hexafluoroisopropanol, and then mounted onto the stents. The fabricated rapamycin-eluting cable-tie stents exhibited excellent mechanical properties on evaluation of compression test and collapse pressure, and less than 8% weight loss following being immersed in phosphate-buffered saline for 16 weeks. Furthermore, the biodegradable stents delivered high rapamycin concentrations for over 4 weeks and achieved substantial reductions in intimal hyperplasia associated with elevated heme oxygenase-1 and calponin level on the denuded rabbit arteries during 6 months of follow-up. The drug-eluting cable-tie type stents developed in this study might have high potential impacts for the local drug delivery to treat various vascular diseases.
引用
收藏
相关论文
共 50 条
  • [21] Pure "cable-tie partial nephrectomy": a porcine model
    Gofrit, Ofer N.
    Harlev, Miki
    Rosenberg, Shilo
    Pode, Dov
    Zorn, Kevin C.
    Shalhav, Arieh L.
    Zamir, Gideon
    Mintz, Yoav
    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, 2010, 24 (12): : 3229 - 3232
  • [22] One-Year Clinical Outcome of a Randomized Trial of Polymer-Free Paclitaxel-Eluting Stents Versus Biodegradable Polymer-Based Rapamycin-Eluting Stents in Patients with Coronary Heart Disease
    Zhang, Lan
    Yuan, Jia
    Liu, Gan
    Zhong, Jin-Peng
    Yin, Yue-Hui
    She, Qiang
    Su, Li
    Ling, Zhi-Yu
    Chen, Yun-qing
    JOURNAL OF INTERVENTIONAL CARDIOLOGY, 2012, 25 (06) : 604 - 610
  • [23] Rapamycin-eluting stents for the treatment of bifurcated coronary lesions:: A randomized comparison of a simple versus complex strategy
    Pan, M
    de Lezo, MS
    Medina, A
    Romero, M
    Segura, J
    Pavlovic, D
    Delgado, A
    Ojeda, S
    Melián, F
    Herrador, J
    Ureña, I
    Burgos, L
    AMERICAN HEART JOURNAL, 2004, 148 (05) : 857 - 864
  • [24] Electrospun Rapamycin-Eluting Polyurethane Fibers for Vascular Grafts
    Han, Jingjia
    Farah, Shady
    Domb, Abraham J.
    Lelkes, Peter I.
    PHARMACEUTICAL RESEARCH, 2013, 30 (07) : 1735 - 1748
  • [25] Electrospun Rapamycin-Eluting Polyurethane Fibers for Vascular Grafts
    Jingjia Han
    Shady Farah
    Abraham J. Domb
    Peter I. Lelkes
    Pharmaceutical Research, 2013, 30 : 1735 - 1748
  • [26] A Randomized Optical Coherence Tomography Study of Coronary Stent Strut Coverage and Luminal Protrusion With Rapamycin-Eluting Stents
    Moore, Philip
    Barlis, Peter
    Spiro, Jonathan
    Ghimire, Gopal
    Roughton, Michael
    Di Mario, Carlo
    Wallis, William
    Ilsley, Charles
    Mitchell, Andrew
    Mason, Mark
    Kharbanda, Rajesh
    Vincent, Peter
    Sherwin, Spencer
    Dalby, Miles
    JACC-CARDIOVASCULAR INTERVENTIONS, 2009, 2 (05) : 437 - 444
  • [27] A NEWLY DEVELOPED RAPAMYCIN-ELUTING STENT WITH A BIODEGRADABLE POLYMER REDUCES NEOINTIMAL FORMATION WHILE ALLOWING GREATER ENDOTHELIALIZATION
    Vorpahl, Marc M.
    Nakazawa, Gaku
    Nebol, Pinar
    Kolodgie, Frank
    Virmani, Renu
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2010, 55 (10)
  • [28] Improved blood compatibility of rapamycin-eluting stent by incorporating curcumin
    Pan, C. J.
    Tang, J. J.
    Shao, Z. Y.
    Wang, J.
    Huang, N.
    COLLOIDS AND SURFACES B-BIOINTERFACES, 2007, 59 (01) : 105 - 111
  • [29] In vitro and in vivo degradation of rapamycin-eluting Mg-Nd-Zn-Zr alloy stents in porcine coronary arteries
    Shi, Yongjuan
    Zhang, Lei
    Chen, Jiahui
    Zhang, Jian
    Yuan, Feng
    Shen, Li
    Chen, Chenxin
    Pei, Jia
    Li, Zhonghua
    Tan, Jinyun
    Yuan, Guangyin
    MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2017, 80 : 1 - 6
  • [30] Cable-tie girdling of peach trees approximates standard girdling results
    Taylor, KC
    JOURNAL OF THE AMERICAN POMOLOGICAL SOCIETY, 2004, 58 (04) : 210 - 214