Synthesis of 2-(2-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole derivatives and evaluation of their antiglycation potential

In the search of potent antidiabetic drug, we synthesized 1–25 2-(2-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole derivatives. First, we synthesized 2-methoxybenzohydrazide from methyl 2-methoxybenzoate which was treated with different arylaldehydes to afford 1–25 compounds. The synthesized compounds were evaluated for antiglycation activity. We found that 1–6 and 8 showed potent activity ranging from 160.2 to 290.17 µM better than standard drug rutin (IC50 = 295.09 ± 1.04 µM). All the synthesized compounds were characterized by different spectroscopy methods. These compounds can further be studied to develop lead antidiabetic compounds.