Synthesis of 2-(2-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole derivatives and evaluation of their antiglycation potential

被引：0

作者：

Muhammad Taha

Nor Hadiani Ismail

Waqas Jamil

Syahrul Imran

Fazal Rahim

Syed Muhammad Kashif

Mohd Zulkefeli

机构：

[1] Universiti Teknologi MARA (UiTM),Atta

[2] UiTM,ur

[3] Hazara University,Rahman Institute for Natural Product Discovery

[4] University of Sindh Jamshoro,Faculty of Applied Science

[5] Universiti Teknologi MARA (UiTM),Department of Chemistry

来源：

Medicinal Chemistry Research | 2016年 / 25卷

关键词：

2-(2-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole; Antiglycation activity; Rutin; Diabetic;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

In the search of potent antidiabetic drug, we synthesized 1–25 2-(2-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole derivatives. First, we synthesized 2-methoxybenzohydrazide from methyl 2-methoxybenzoate which was treated with different arylaldehydes to afford 1–25 compounds. The synthesized compounds were evaluated for antiglycation activity. We found that 1–6 and 8 showed potent activity ranging from 160.2 to 290.17 µM better than standard drug rutin (IC50 = 295.09 ± 1.04 µM). All the synthesized compounds were characterized by different spectroscopy methods. These compounds can further be studied to develop lead antidiabetic compounds.

引用

页码：225 / 234

页数：9

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