R-sulforaphane modulates the expression profile of AhR, ERα, Nrf2, NQO1, and GSTP in human breast cell lines
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作者:
Barbara Licznerska
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机构:Poznan University of Medical Sciences,Department of Pharmaceutical Biochemistry
Barbara Licznerska
Hanna Szaefer
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机构:Poznan University of Medical Sciences,Department of Pharmaceutical Biochemistry
Hanna Szaefer
Violetta Krajka-Kuźniak
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机构:Poznan University of Medical Sciences,Department of Pharmaceutical Biochemistry
Violetta Krajka-Kuźniak
机构:
[1] Poznan University of Medical Sciences,Department of Pharmaceutical Biochemistry
来源:
Molecular and Cellular Biochemistry
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2021年
/
476卷
关键词:
Sulforaphane;
Nrf2;
NQO1;
GSTP;
AhR;
Breast cells;
D O I:
暂无
中图分类号:
学科分类号:
摘要:
Our previous study showed remarkable differences in the effect of R-sulforaphane (R-SFN) on the expression of CYPs 19, 1A1, 1A2, and 1B1 in ER(+) MCF7, ER( −) MDA-MB-231, and non-tumorigenic immortalized MCF10A (8). This study aimed to evaluate the effect of R-SFN on phase II enzymes induction and expression of AhR, Nrf2, and ERα in the same breast cell lines. The results showed increased expression of GSTP as a result of treatment with R-SFN in breast cancer cells. An increased NQO1 transcript and protein levels were found in all breast cells, with the most significant increase in MCF7 cells. Similarly, the enhancement of Nrf2 expression was noticed in all tested cells. AhR gene transcript and protein were decreased in MCF7 cells. In MDA-MB-231, increased AhR mRNA was not confirmed at the protein level. No differences were found in the expression of ERα. Overall, the results of the present study extended our earlier suggestions on the possible interference of R-SFN with estrogens homeostasis in breast cancer cells differing in ERα status, as well as in non-tumorigenic immortalized breast epithelial cells. While some of R-SFN effects might be beneficial and useful in breast cancer prevention, the others, particularly GSTP induction, may lead to adverse effects.
机构:
China Pharmaceut Univ, Sch Tradit Chinese Pharm, Dept Pharmacol Chinese Mat Med, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R ChinaChina Pharmaceut Univ, Sch Tradit Chinese Pharm, Dept Pharmacol Chinese Mat Med, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China
Wang, Kai
Lv, Qi
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China Pharmaceut Univ, Sch Tradit Chinese Pharm, Dept Pharmacol Chinese Mat Med, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R ChinaChina Pharmaceut Univ, Sch Tradit Chinese Pharm, Dept Pharmacol Chinese Mat Med, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China
Lv, Qi
Miao, Yu-meng
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机构:
China Pharmaceut Univ, Sch Tradit Chinese Pharm, Dept Pharmacol Chinese Mat Med, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R ChinaChina Pharmaceut Univ, Sch Tradit Chinese Pharm, Dept Pharmacol Chinese Mat Med, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China
Miao, Yu-meng
Qiao, Si-miao
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China Pharmaceut Univ, Sch Tradit Chinese Pharm, Dept Pharmacol Chinese Mat Med, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R ChinaChina Pharmaceut Univ, Sch Tradit Chinese Pharm, Dept Pharmacol Chinese Mat Med, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China
Qiao, Si-miao
Dai, Yue
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China Pharmaceut Univ, Sch Tradit Chinese Pharm, Dept Pharmacol Chinese Mat Med, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R ChinaChina Pharmaceut Univ, Sch Tradit Chinese Pharm, Dept Pharmacol Chinese Mat Med, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China
Dai, Yue
Wei, Zhi-feng
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China Pharmaceut Univ, Sch Tradit Chinese Pharm, Dept Pharmacol Chinese Mat Med, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R ChinaChina Pharmaceut Univ, Sch Tradit Chinese Pharm, Dept Pharmacol Chinese Mat Med, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China
机构:
Sichuan Univ, West China Sch Pharm, Dept Clin Pharm & Pharm Adm, Chengdu, Sichuan, Peoples R ChinaSichuan Univ, West China Sch Pharm, Dept Clin Pharm & Pharm Adm, Chengdu, Sichuan, Peoples R China
Yang, Yujie
Wang, Yanran
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Sichuan Univ, West China Sch Pharm, Dept Clin Pharm & Pharm Adm, Chengdu, Sichuan, Peoples R ChinaSichuan Univ, West China Sch Pharm, Dept Clin Pharm & Pharm Adm, Chengdu, Sichuan, Peoples R China
Wang, Yanran
Wang, Ting
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Sichuan Univ, West China Sch Pharm, Dept Clin Pharm & Pharm Adm, Chengdu, Sichuan, Peoples R China
Sichuan Canc Hosp & Inst, Sichuan Canc Ctr, Dept Pharm, Chengdu, Sichuan, Peoples R ChinaSichuan Univ, West China Sch Pharm, Dept Clin Pharm & Pharm Adm, Chengdu, Sichuan, Peoples R China
Wang, Ting
Jiang, Xuehua
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Sichuan Univ, West China Sch Pharm, Dept Clin Pharm & Pharm Adm, Chengdu, Sichuan, Peoples R ChinaSichuan Univ, West China Sch Pharm, Dept Clin Pharm & Pharm Adm, Chengdu, Sichuan, Peoples R China
机构:
Univ So Calif, Keck Sch Med, Dept Biochem & Mol Biol, Los Angeles, CA 90033 USAUniv So Calif, Keck Sch Med, Dept Biochem & Mol Biol, Los Angeles, CA 90033 USA
Yeligar, Samantha M.
Machida, Keigo
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Univ So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USAUniv So Calif, Keck Sch Med, Dept Biochem & Mol Biol, Los Angeles, CA 90033 USA
Machida, Keigo
Kalra, Vijay K.
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Univ So Calif, Keck Sch Med, Dept Biochem & Mol Biol, Los Angeles, CA 90033 USAUniv So Calif, Keck Sch Med, Dept Biochem & Mol Biol, Los Angeles, CA 90033 USA
机构:
Chongqing Med Univ, Yong Chuan Hosp, Cent Lab, Chongqing 402160, Peoples R ChinaChongqing Med Univ, Yong Chuan Hosp, Cent Lab, Chongqing 402160, Peoples R China
Chu, Xuan
Zhong, Liang
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Chongqing Med Univ, Dept Lab Med, Key Lab Lab Med Diagnost, Minist Educ, Chongqing 400016, Peoples R ChinaChongqing Med Univ, Yong Chuan Hosp, Cent Lab, Chongqing 402160, Peoples R China
Zhong, Liang
Dan, Wenran
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Chongqing Med Univ, Yong Chuan Hosp, Cent Lab, Chongqing 402160, Peoples R ChinaChongqing Med Univ, Yong Chuan Hosp, Cent Lab, Chongqing 402160, Peoples R China
Dan, Wenran
Wang, Xiao
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Chongqing Med Univ, Yong Chuan Hosp, Cent Lab, Chongqing 402160, Peoples R ChinaChongqing Med Univ, Yong Chuan Hosp, Cent Lab, Chongqing 402160, Peoples R China
Wang, Xiao
Zhang, Zhonghui
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Chongqing Med Univ, Yong Chuan Hosp, Cent Lab, Chongqing 402160, Peoples R ChinaChongqing Med Univ, Yong Chuan Hosp, Cent Lab, Chongqing 402160, Peoples R China
Zhang, Zhonghui
Liu, Zhenyan
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Chongqing Med Univ, Yong Chuan Hosp, Cent Lab, Chongqing 402160, Peoples R ChinaChongqing Med Univ, Yong Chuan Hosp, Cent Lab, Chongqing 402160, Peoples R China
Liu, Zhenyan
Lu, Yang
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Chongqing Med Univ, Yong Chuan Hosp, Cent Lab, Chongqing 402160, Peoples R ChinaChongqing Med Univ, Yong Chuan Hosp, Cent Lab, Chongqing 402160, Peoples R China
Lu, Yang
Shao, Xin
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Chongqing Med Univ, Yong Chuan Hosp, Cent Lab, Chongqing 402160, Peoples R ChinaChongqing Med Univ, Yong Chuan Hosp, Cent Lab, Chongqing 402160, Peoples R China
Shao, Xin
Zhou, Ziwei
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Chongqing Med Univ, Yong Chuan Hosp, Cent Lab, Chongqing 402160, Peoples R ChinaChongqing Med Univ, Yong Chuan Hosp, Cent Lab, Chongqing 402160, Peoples R China
Zhou, Ziwei
Chen, Shuyu
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Chongqing Med Univ, Yong Chuan Hosp, Cent Lab, Chongqing 402160, Peoples R ChinaChongqing Med Univ, Yong Chuan Hosp, Cent Lab, Chongqing 402160, Peoples R China
Chen, Shuyu
Liu, Beizhong
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Chongqing Med Univ, Yong Chuan Hosp, Cent Lab, Chongqing 402160, Peoples R China
Chongqing Med Univ, Dept Lab Med, Key Lab Lab Med Diagnost, Minist Educ, Chongqing 400016, Peoples R ChinaChongqing Med Univ, Yong Chuan Hosp, Cent Lab, Chongqing 402160, Peoples R China