Modelling intra-host competition between malaria parasites strains

被引：0
|
作者：
Tianqi Song
Chuncheng Wang
Boping Tian
机构：
[1] Harbin Institute of Technology,School of Mathematics
来源：
Computational and Applied Mathematics | 2020年 / 39卷
关键词：
Epidemiological model; Malaria parasites; Drug treatment; Intra-host competition; 92B05; 34D20;
D O I：
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学科分类号：
摘要：
An intra-host epidemiological model is formulated for the co-infection of drug-sensitive and drug-resistant malaria parasites to examine the impact of aggressive treatment on the effect of competitive release in an infected host. The analysis of the existence of equilibrium and their stability of the model is conducted, and the results reveal that the intra-host competition and treatment play a key role in the prevalence of drug-resistant strains. The mathematical outcomes qualitatively match the experimental fact, that the rapid elimination of drug-resistant strains could promote the very evolution it is intended to retard.
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