Difficulty diagnosing chronic cryptococcal meningitis in idiopathic CD4+ lymphocytopenia

被引:0
|
作者
Giuseppe Sancesario
Giampiero Palmieri
Gemma Viola
Carla Fontana
Alessandra Perfetti
Lucia Anemona
Roberto Floris
Simone Marziali
Giorgio Bernardi
Luigi Giusto Spagnoli
机构
[1] Università di Roma Tor Vergata,Dipartimento di Neuroscienze
[2] University of Rome Tor Vergata,Department of Biopathology
[3] University of Rome Tor Vergata,Department of Internal Medicine
[4] Santa Lucia Foundation,undefined
来源
Neurological Sciences | 2011年 / 32卷
关键词
Cryptococcosis; Idiopathic CD4 lymphocytopenia; Macrophages; Electron microscopy;
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学科分类号
摘要
A 64-year-old man with idiopathic CD4+ lymphocytopenia developed cognitive impairment and gait ataxia with isolated obstructive hydrocephalus, which was fatal. Cerebrospinal fluid showed mild pleocytosis, but the etiology was not revealed by extensive analysis. At autopsy, inflammatory cells, CD8+ lymphocytes and abundant macrophages but not CD4+ lymphocytes were infiltrating the meninges at the base of the brain. Electron microscopy demonstrated that inflammation was caused by Cryptococcus neoformans, which was localized exclusively within macrophages, where it grew with budding. Our study suggests that, in idiopathic CD4+ lymphocytopenia, macrophages can efficiently phagocytize but inefficiently digest C. neoformans, thus representing a vehicle of chronic intracellular infection.
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页码:519 / 524
页数:5
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