Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia

被引：0

作者：

Christopher N Hahn

Chan-Eng Chong

Catherine L Carmichael

Ella J Wilkins

Peter J Brautigan

Xiao-Chun Li

Milena Babic

Ming Lin

Amandine Carmagnac

Young K Lee

Chung H Kok

Lucia Gagliardi

Kathryn L Friend

Paul G Ekert

Carolyn M Butcher

Anna L Brown

Ian D Lewis

L Bik To

Andrew E Timms

Jan Storek

Sarah Moore

Meryl Altree

Robert Escher

Peter G Bardy

Graeme K Suthers

Richard J D'Andrea

Marshall S Horwitz

Hamish S Scott

机构：

[1] Centre for Cancer Biology,Department of Molecular Pathology

[2] SA Pathology,Molecular Medicine Division

[3] School of Medicine,Department of Haematology and Oncology

[4] University of Adelaide,Department of Haematology

[5] Walter and Eliza Hall Institute of Medical Research,Department of Paediatric and Reproductive Genetics

[6] The Queen Elizabeth Hospital,Cell Signalling and Cell Death Division

[7] Centre for Cancer Biology,Department of Pathology

[8] SA Pathology,Department of Medicine

[9] SA Pathology,Department of Paediatrics

[10] Walter and Eliza Hall Institute of Medical Research,undefined

[11] University of Washington School of Medicine,undefined

[12] University of Calgary,undefined

[13] SA Clinical Genetics Service,undefined

[14] SA Pathology,undefined

[15] University of Adelaide,undefined

[16] School of Molecular and Biomedical Science,undefined

[17] University of Adelaide,undefined

[18] Present addresses: Neurogenetics Laboratory,undefined

[19] Howard Florey Institute,undefined

[20] Parkville,undefined

[21] Victoria,undefined

[22] Australia (E.J.W.) and Medical Clinic,undefined

[23] Regional Hospital Emmental,undefined

[24] Burgdorf,undefined

[25] Switzerland (R.E.).,undefined

来源：

Nature Genetics | 2011年 / 43卷

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摘要：

Hamish Scott and colleagues report that germline mutations in GATA2 segregate with myelodysplastic syndrome and acute myeloid leukemia in four pedigrees. The resulting alterations occur in a conserved zinc finger DNA-binding domain of GATA2.

引用

页码：1012 / 1017

页数：5

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