Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

被引：0

作者：

Travis K. Warren

Robert Jordan

Michael K. Lo

Adrian S. Ray

Richard L. Mackman

Veronica Soloveva

Dustin Siegel

Michel Perron

Roy Bannister

Hon C. Hui

Nate Larson

Robert Strickley

Jay Wells

Kelly S. Stuthman

Sean A. Van Tongeren

Nicole L. Garza

Ginger Donnelly

Amy C. Shurtleff

Cary J. Retterer

Dima Gharaibeh

Rouzbeh Zamani

Tara Kenny

Brett P. Eaton

Elizabeth Grimes

Lisa S. Welch

Laura Gomba

Catherine L. Wilhelmsen

Donald K. Nichols

Jonathan E. Nuss

Elyse R. Nagle

Jeffrey R. Kugelman

Gustavo Palacios

Edward Doerffler

Sean Neville

Ernest Carra

Michael O. Clarke

Lijun Zhang

Willard Lew

Bruce Ross

Queenie Wang

Kwon Chun

Lydia Wolfe

Darius Babusis

Yeojin Park

Kirsten M. Stray

Iva Trancheva

Joy Y. Feng

Ona Barauskas

Yili Xu

Pamela Wong

机构：

[1] United States Army Medical Research Institute of Infectious Diseases,

[2] United States Army Medical Research Institute of Infectious Diseases,undefined

[3] Therapeutic Development Center,undefined

[4] Gilead Sciences,undefined

[5] Centers for Disease Control and Prevention,undefined

[6] Boston University School of Medicine,undefined

[7] †Present addresses: LOKET Consulting,undefined

[8] Clarksburg,undefined

[9] Maryland 20871,undefined

[10] USA (L.S.W.); Cocrystal Pharma,undefined

[11] Tucker,undefined

[12] Georgia 30084,undefined

[13] USA (D.L.M).,undefined

来源：

Nature | 2016年 / 531卷

关键词：

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中图分类号：

学科分类号：

摘要：

The discovery is reported of a small molecule drug, GS-5734, which has antiviral activity against Ebola virus and other filoviruses, and is capable of providing post-exposure therapeutic protection against lethal disease in 100% of drug-treated nonhuman primates infected with Ebola virus; the drug targets viral RNA polymerase and can distribute to sanctuary sites (such as testes, eyes and brain), suggesting that it may be able to clear persistent virus infection.

引用

页码：381 / 385

页数：4

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