Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

被引：0
|
作者：
Travis K. Warren
Robert Jordan
Michael K. Lo
Adrian S. Ray
Richard L. Mackman
Veronica Soloveva
Dustin Siegel
Michel Perron
Roy Bannister
Hon C. Hui
Nate Larson
Robert Strickley
Jay Wells
Kelly S. Stuthman
Sean A. Van Tongeren
Nicole L. Garza
Ginger Donnelly
Amy C. Shurtleff
Cary J. Retterer
Dima Gharaibeh
Rouzbeh Zamani
Tara Kenny
Brett P. Eaton
Elizabeth Grimes
Lisa S. Welch
Laura Gomba
Catherine L. Wilhelmsen
Donald K. Nichols
Jonathan E. Nuss
Elyse R. Nagle
Jeffrey R. Kugelman
Gustavo Palacios
Edward Doerffler
Sean Neville
Ernest Carra
Michael O. Clarke
Lijun Zhang
Willard Lew
Bruce Ross
Queenie Wang
Kwon Chun
Lydia Wolfe
Darius Babusis
Yeojin Park
Kirsten M. Stray
Iva Trancheva
Joy Y. Feng
Ona Barauskas
Yili Xu
Pamela Wong
机构：
[1] United States Army Medical Research Institute of Infectious Diseases,
[2] United States Army Medical Research Institute of Infectious Diseases,undefined
[3] Therapeutic Development Center,undefined
[4] Gilead Sciences,undefined
[5] Centers for Disease Control and Prevention,undefined
[6] Boston University School of Medicine,undefined
[7] †Present addresses: LOKET Consulting,undefined
[8] Clarksburg,undefined
[9] Maryland 20871,undefined
[10] USA (L.S.W.); Cocrystal Pharma,undefined
[11] Tucker,undefined
[12] Georgia 30084,undefined
[13] USA (D.L.M).,undefined
来源：
Nature | 2016年 / 531卷
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摘要：
The discovery is reported of a small molecule drug, GS-5734, which has antiviral activity against Ebola virus and other filoviruses, and is capable of providing post-exposure therapeutic protection against lethal disease in 100% of drug-treated nonhuman primates infected with Ebola virus; the drug targets viral RNA polymerase and can distribute to sanctuary sites (such as testes, eyes and brain), suggesting that it may be able to clear persistent virus infection.
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页码：381 / 385
页数：4
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