A hepatocyte growth factor receptor (Met)−insulin receptor hybrid governs hepatic glucose metabolism

被引：0

作者：

Arlee Fafalios

Jihong Ma

Xinping Tan

John Stoops

Jianhua Luo

Marie C DeFrances

Reza Zarnegar

机构：

[1] University of Pittsburgh,Department of Pathology

[2] McGowan Institute of Regenerative Medicine,undefined

[3] University of Pittsburgh,undefined

[4] University of Pittsburgh Cancer Institute,undefined

来源：

Nature Medicine | 2011年 / 17卷

关键词：

D O I：

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中图分类号：

学科分类号：

摘要：

It is well regarded that insulin receptor signaling in the liver is key to proper metabolic control. Reza Zarnegar and his colleagues now show that the hepatocyte growth factor receptor, Met, physically interacts with the insulin receptor signaling complex, potentiating the latter's signaling. They also show that Met signaling restores insulin responsiveness in a mouse model of insulin resistance, suggesting a potentially new therapeutic avenue to treat prediabetes.

引用

页码：1577 / 1584

页数：7

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