A hepatocyte growth factor receptor (Met)−insulin receptor hybrid governs hepatic glucose metabolism

被引：0
|
作者：
Arlee Fafalios
Jihong Ma
Xinping Tan
John Stoops
Jianhua Luo
Marie C DeFrances
Reza Zarnegar
机构：
[1] University of Pittsburgh,Department of Pathology
[2] McGowan Institute of Regenerative Medicine,undefined
[3] University of Pittsburgh,undefined
[4] University of Pittsburgh Cancer Institute,undefined
来源：
Nature Medicine | 2011年 / 17卷
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摘要：
It is well regarded that insulin receptor signaling in the liver is key to proper metabolic control. Reza Zarnegar and his colleagues now show that the hepatocyte growth factor receptor, Met, physically interacts with the insulin receptor signaling complex, potentiating the latter's signaling. They also show that Met signaling restores insulin responsiveness in a mouse model of insulin resistance, suggesting a potentially new therapeutic avenue to treat prediabetes.
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页码：1577 / 1584
页数：7
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