The faces and friends of RhoGDI2

被引：0

作者：

Erin M. Griner

Dan Theodorescu

机构：

[1] University of Virginia,Center for Cell Signaling and Department of Microbiology, Immunology and Cancer Biology

[2] University of Colorado,Department of Pharmacology

[3] University of Colorado Comprehensive Cancer Center,Department of Surgery

[4] University of Colorado Comprehensive Cancer Center,undefined

来源：

Cancer and Metastasis Reviews | 2012年 / 31卷

关键词：

RhoGDI2; GTPase; Metastasis; Bladder neoplasms;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

RhoGDI2 is a guanine nucleotide dissociation inhibitor (GDI) specific for the Rho family of small GTPases that plays dual opposite roles in tumor progression, being both a promoter in tissues such as breast and a metastasis suppressor in tissues such as the bladder. Despite a clear role for this protein in modulating the invasive and metastatic process, the mechanisms through which RhoGDI2 executes these functions remain unclear. This review will highlight the current state of our knowledge regarding how RhoGDI2 functions in metastasis with a focus on bladder cancer and will also seek to highlight other potential underappreciated avenues through which this protein may affect cancer cell behavior.

引用

页码：519 / 528

页数：9

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