SARS-CoV-2 nucleocapsid protein undergoes liquid–liquid phase separation into stress granules through its N-terminal intrinsically disordered region

被引：0
|
作者：
Jia Wang
Chengrui Shi
Qun Xu
Hang Yin
机构：
[1] Tsinghua University,School of Pharmaceutical Sciences
[2] Tsinghua University,Tsinghua
[3] Tsinghua University,Peking Center for Life Sciences
[4] Tsinghua University,Beijing Advanced Innovation Center for Structural Biology
来源：
Cell Discovery | / 7卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [21] Characterizing nucleic acid interactions with the N-Terminal binding domain of the SARS-CoV-2 nucleocapsid protein
    Cubuk, Jasmine
    Incicco, Juan J.
    Stuchell-Brereton, Melissa D.
    Hall, Kathleen B.
    Soranno, Andrea
    BIOPHYSICAL JOURNAL, 2022, 121 (03) : 213A - 214A
  • [22] Liquid-liquid phase separation of nucleocapsid proteins during SARS-CoV-2 and HIV-1 replication
    Chau, Bao-An
    Chen, Venessa
    Cochrane, Alan W.
    Parent, Leslie J.
    Mouland, Andrew J.
    CELL REPORTS, 2023, 42 (01):
  • [23] Targeting liquid-liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity
    Wang, Shuai
    Dai, Tong
    Qin, Ziran
    Pan, Ting
    Chu, Feng
    Lou, Lingfeng
    Zhang, Long
    Yang, Bing
    Huang, Huizhe
    Lu, Huasong
    Zhou, Fangfang
    NATURE CELL BIOLOGY, 2021, 23 (07) : 718 - +
  • [24] Phase separation underlies interactions of the SARS-CoV-2 nucleocapsid protein with nucleoli
    Dogra, Priyanka
    Shirnekhi, Hazheen
    Ferrolino, Mylene C.
    Tolbert, Michele
    Park, Cheon-Gil
    Kriwacki, Richard W.
    BIOPHYSICAL JOURNAL, 2023, 122 (03) : 205A - 205A
  • [25] Phase separation by the SARS-CoV-2 nucleocapsid protein: Consensus and open questions
    Cascarina, Sean M.
    Ross, Eric D.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2022, 298 (03)
  • [26] Insights into the specificity for the interaction of the promiscuous SARS-CoV-2 nucleocapsid protein N-terminal domain with deoxyribonucleic acids
    Caruso, Icaro Putinhon
    Almeida, Vitor dos Santos
    do Amaral, Mariana Juliani
    de Andrade, Guilherme Caldas
    de Araujo, Gabriela Rocha
    de Araujo, Talita Stelling
    de Azevedo, Jessica Moreira
    Barbosa, Glauce Moreno
    Bartkevihi, Leonardo
    Bezerra, Peter Reis
    dos Santos Cabral, Katia Maria
    de Lourenco, Isabella Otenio
    Malizia-Motta, Clara L. F.
    Marques, Aline de Luna
    Mebus-Antunes, Nathane Cunha
    Neves-Martins, Thais Cristtina
    de Sa, Jessica Marostica
    Sanches, Karoline
    Santana-Silva, Marcos Caique
    Vasconcelos, Ariana Azevedo
    Almeida, Marcius da Silva
    de Amorim, Gisele Cardoso
    Anobom, Cristiane Dinis
    Da Poian, Andrea T.
    Gomes-Neto, Francisco
    Pinheiro, Anderson S.
    Almeida, Fabio C. L.
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2022, 203 : 466 - 480
  • [27] A review of the effects of ATP and hydroxychloroquine on the phase separation of the SARS-CoV-2 nucleocapsid protein
    Dang, Mei
    Song, Jianxing
    BIOPHYSICAL REVIEWS, 2022, 14 (03) : 709 - 715
  • [28] A review of the effects of ATP and hydroxychloroquine on the phase separation of the SARS-CoV-2 nucleocapsid protein
    Mei Dang
    Jianxing Song
    Biophysical Reviews, 2022, 14 : 709 - 715
  • [29] The SARS-CoV-2 nucleocapsid protein suppresses innate immunity by remodeling stress granules to atypical foci
    He, Su
    Gou, Hongwei
    Zhou, Yulin
    Wu, Chunxiu
    Ren, Xinxin
    Wu, Xiajunpeng
    Guan, Guanwen
    Jin, Boxing
    Huang, Jinhua
    Jin, Zhigang
    Zhao, Tiejun
    FASEB JOURNAL, 2023, 37 (12):
  • [30] Mechanistic and thermodynamic characterization of antiviral inhibitors targeting nucleocapsid N-terminal domain of SARS-CoV-2
    Dhaka, Preeti
    Singh, Ankur
    Choudhary, Shweta
    Peddinti, Rama Krishna
    Kumar, Pravindra
    Sharma, Gaurav Kumar
    Tomar, Shailly
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2023, 750
12345