Thinking bedside at the bench: the NOD mouse model of T1DM

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作者
James C. Reed
Kevan C. Herold
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[1] Department of Immunobiology,Department of Immunobiology, Department of Internal Medicine
[2] Yale University,undefined
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Successful studies in the nonobese diabetic (NOD) mouse model often do not translate to positive outcomes in human studies. This Perspectives outlines the genetic and immunologic differences that might contribute to these differential outcomes and suggests how the NOD mouse model could be adapted to improve its utility.
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页码:308 / 314
页数:6
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