Understanding the mechanisms and translational implications of the microbiome for cancer therapy innovation

被引：0
|
作者：
Jessica Queen
Fyza Shaikh
Cynthia L. Sears
机构：
[1] Johns Hopkins University School of Medicine,Division of Infectious Diseases, Department of Medicine
[2] Johns Hopkins University School of Medicine,Cancer Immunology Program, Department of Oncology
[3] Bloomberg School of Public Health,Department of Microbiology and Molecular Immunology
来源：
Nature Cancer | 2023年 / 4卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The intersection of the microbiota and cancer and the mechanisms that define these interactions are a fascinating, rapidly evolving area of cancer biology and therapeutics. Here we present recent insights into the mechanisms by which specific bacteria or their communities contribute to carcinogenesis and discuss the bidirectional interplay between microbiota and host gene or epigenome signaling. We conclude with comments on manipulation of the microbiota for the therapeutic benefit of patients with cancer.
引用
收藏
页码：1083 / 1094
页数：11
相关论文
共 50 条
  • [21] Mechanisms of Hedgehog pathway activation in cancer and implications for therapy
    Scales, Suzie J.
    de Sauvage, Frederic J.
    TRENDS IN PHARMACOLOGICAL SCIENCES, 2009, 30 (06) : 303 - 312
  • [22] The bronchiectasis microbiome: current understanding and treatment implications
    Narayana, Jayanth Kumar
    Mac Aogain, Micheal
    Hansbro, Philip M.
    Chotirmall, Sanjay H.
    CURRENT OPINION IN PULMONARY MEDICINE, 2025, 31 (02) : 135 - 144
  • [23] Ferroptosis: mechanisms and implications for cancer development and therapy response
    dos Santos, Ancely Ferreira
    Fazeli, Gholamreza
    da Silva, Thamara Nishida Xavier
    Angeli, Jose Pedro Friedmann
    TRENDS IN CELL BIOLOGY, 2023, 33 (12) : 1062 - 1076
  • [24] Angiogenesis: From molecular mechanisms to translational implications
    Li, Bingwei
    Xiu, Ruijuan
    CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, 2013, 54 (04) : 345 - 355
  • [25] Editorial: Myocardial Remodeling: Mechanisms and Translational Implications
    Roncalli, Jerome
    Tronchere, Helene
    Lax, Antonio
    Kunduzova, Oxana
    FRONTIERS IN PHARMACOLOGY, 2022, 13
  • [26] Targeting of cancer cell death mechanisms by curcumin: Implications to cancer therapy
    Yu, Chong
    Yang, Bo
    Najafi, Masoud
    BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2021, 129 (06) : 397 - 415
  • [27] The role of histone post-translational modifications in cancer and cancer immunity: functions, mechanisms and therapeutic implications
    Duan, Xiaohong
    Xing, Zhiyao
    Qiao, Lu
    Qin, Shan
    Zhao, Xuejing
    Gong, Yanhua
    Li, Xueren
    FRONTIERS IN IMMUNOLOGY, 2024, 15
  • [28] Potential influence of the microbiome environment in patients with biliary tract cancer and implications for therapy
    Wheatley, Roseanna C.
    Kilgour, Elaine
    Jacobs, Timothy
    Lamarca, Angela
    Hubner, Richard A.
    Valle, Juan W.
    McNamara, Mairead G.
    BRITISH JOURNAL OF CANCER, 2022, 126 (05) : 693 - 705
  • [29] Interplay between the Human Microbiome and Biliary Tract Cancer: Implications for Pathogenesis and Therapy
    Ye, Cheng
    Dong, Chunlu
    Lin, Yanyan
    Shi, Huaqing
    Zhou, Wence
    MICROORGANISMS, 2023, 11 (10)
  • [30] Potential influence of the microbiome environment in patients with biliary tract cancer and implications for therapy
    Roseanna C. Wheatley
    Elaine Kilgour
    Timothy Jacobs
    Angela Lamarca
    Richard A. Hubner
    Juan W. Valle
    Mairéad G. McNamara
    British Journal of Cancer, 2022, 126 : 693 - 705
12345