IsproniclineA novel α4β2 nicotinic acetylcholine receptor-selective agonist with cognition-enhancing and neuroprotective properties

被引：0
|
作者：
Patrick Lippiello
Sharon R. Letchworth
Gregory J. Gatto
Vincent M. Traina
Merouane Bencherif
机构：
[1] Targacept,Preclinical Research
[2] Inc.,undefined
来源：
Journal of Molecular Neuroscience | 2006年 / 30卷
关键词：
Nicotinic Acetylcholine Receptor; Molecular Neuroscience Volume; Striatal Dopamine Release; Neuronal nAChR; nAChR Agonist;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：19 / 20
页数：1
相关论文
共 50 条
  • [31] (+)-Laburnamine, a Natural Selective Ligand and Partial Agonist for the α4β2 Nicotinic Receptor Subtype
    Tasso, Bruno
    Novelli, Federica
    Sparatore, Fabio
    Fasoli, Francesca
    Gotti, Cecilia
    JOURNAL OF NATURAL PRODUCTS, 2013, 76 (04): : 727 - 731
  • [32] Novel methyllycaconitine analogues selective for the α4β2 over α7 nicotinic acetylcholine receptors
    Gallagher, Ryan
    Qudah, Taima
    Balle, Thomas
    Chebib, Mary
    McLeod, Malcolm D.
    BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 51
  • [33] Agonist properties of putative small-molecule somatostatin sst2 receptor-selective antagonists
    Nunn, C
    Langenegger, D
    Hurth, K
    Schmidt, K
    Fehlmann, D
    Hoyer, D
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2003, 465 (03) : 211 - 218
  • [34] Additional Acetylcholine (ACh) Binding Site at α4/α4 Interface of (α4β2)2α4 Nicotinic Receptor Influences Agonist Sensitivity
    Mazzaferro, Simone
    Benallegue, Nail
    Carbone, Anna
    Gasparri, Federica
    Vijayan, Ranjit
    Biggin, Philip C.
    Moroni, Mirko
    Bermudez, Isabel
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (35) : 31043 - 31054
  • [35] SSR591813, a novel selective and partial α4β2 nicotinic receptor agonist with potential as an aid to smoking cessation
    Cohen, C
    Bergis, OE
    Galli, F
    Lochead, AW
    Jegham, S
    Biton, B
    Léonardon, J
    Avenet, P
    Sgard, F
    Besnard, F
    Graham, D
    Coste, A
    Oblin, A
    Curet, O
    Voltz, C
    Gardes, A
    Caille, D
    Perrault, G
    George, P
    Soubrié, P
    Scatton, B
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2003, 306 (01): : 407 - 420
  • [36] Peripheral α4β2 nicotinic acetylcholine receptor agonist attenuates macrophage induced neuroinflammation and neuropathic pain
    Saika, Fumihiro
    Kiguchi, Norikazu
    Matsuzaki, Shinsuke
    Kishioka, Shiroh
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2016, 130 (03) : S234 - S234
  • [37] Ispronicline.: Nicotinic acetylcholine α4β2 agonist Treatment of cognition disorders (vol 33, pg 197, 2008)
    Owen, R. T.
    Serradell, N.
    Rosa, E.
    DRUGS OF THE FUTURE, 2008, 33 (06) : 556 - 556
  • [38] Synthesis, Pharmacology, and Biostructural Characterization of Novel α4β2 Nicotinic Acetylcholine Receptor Agonists
    Ussing, Christine A.
    Hansen, Camilla P.
    Petersen, Jette G.
    Jensen, Anders A.
    Rohde, Line A. H.
    Ahring, Philip K.
    Nielsen, Elsebet O.
    Kastrup, Jette S.
    Gajhede, Michael
    Frolund, Bente
    Balle, Thomas
    JOURNAL OF MEDICINAL CHEMISTRY, 2013, 56 (03) : 940 - 951
  • [39] Dianicline, a Novel α4β2 Nicotinic Acetylcholine Receptor Partial Agonist, for Smoking Cessation: A Randomized Placebo-Controlled Clinical Trial
    Tonstad, Serena
    Holme, Ingar
    Tonnesen, Philip
    NICOTINE & TOBACCO RESEARCH, 2011, 13 (01) : 8 - 13
  • [40] Design and Synthesis of α-Conotoxin GID Analogues as Selective α4β2 Nicotinic Acetylcholine Receptor Antagonists
    Banerjee, Jayati
    Yongye, Austin B.
    Chang, Yi-Pin
    Gyanda, Reena
    Medina-Franco, Jose L.
    Armishaw, Christopher J.
    BIOPOLYMERS, 2014, 102 (01) : 78 - 87
12345